M.H.A. Beg ( Department of Otolaryngology, K.V. SITE Hospital, Karachi. )
A. Qayum ( Department of Otolaryngology, K.V. SITE Hospital, Karachi. )
Cryosurgery was used in 100 cases with various lesions in the ear, nose and throat over a period ranging from early 1980 to the end of 1981. It was found to be a safe, convenient and can be done under a local anaesthetic in the out-patients department. Vasomotor Rhinitis was the commonest indication for cryosurgery in our series. Satisfactory results were also obtained in cases of Epistaxis, Haemangiomas and Leukoplakia. It did not prove useful in malignant lesions (JPMA 32:183, 1982).
Cryotherapy is the application of temperatures below freezing point to tissues, resulting in injury and subsequent cell death. The principle was first introduced by Arnott in 1851 when he irrigated superficial tumours with ice cold brine solutions. Later liquid nitrogen was used in an improved process by Cooper and Lee (1961). Lewis and Cahan treated five tumours of the Glomus Jugulare successfully with cryosurgery in 1967. The cryoprobe was put to a more extensive use by Holden (1972) and Ozenberger (1973).
The changes seen in the tissues after cryotherapy are first rupture of the cell membrane followed by intracellular dehydration, protein denaturation and disruption of cell metabolism causing local ischaemia and micro-thrombosis (Holden, 1973).
The required temperature for cell death is -20°C. (Karja et al., 1975). Further lowering the temperature does not increase the lethality to the cells. Cooling should be carried out rapidly and then the tissues be allowed to thaw slowly. Repitition of the freeze-thaw cycle makes the therapy more effective. Adjusting the probe temperature and the application time controls the width of the cryolesion.
The macroscopic changes seen after cryotherapy are hyperaemia, congestion and inflammation. This is followed by definite necrosis and slough formation. The slough separates leaving a clean granulating area which heals rapidly with little or no scarring.
Material and Methods
The instrument used was Frigitonies CM73 with Nitrous Oxide to provide temperatures upto a minimum of -89°C. The working is based oil the Joule Thomson Principle where the rapidly expanding gas passing through a narrow aperture brings about the cooling effect. Six interchangeable screw-on-probes were handy for selection (Figure 1 and 2).
Hundred cases were selected for cryotherapy of which 96 were out-patients. The anaesthetic used was 4% Lignocaine and Vasomotor Rhinitis was the commonest condition (Table I).
In our series of 100 patients, Vasomotor Rhinitis showed the most satisfactory response to cryotherapy. The side-on probe which is insulated, was found to be very safe as it protects the nasal septum on the other side. Similar observations were made by Bicknell (1979). Earlier Tullegrass (Holden, 1972) and silicone (Ozenberger, 1973) have been used to save the nasal Septum.
Good results in cases of leukoplakia treated with cryosurgery have been reported by Poswillo (1976) and Goode and Spooner (1971). Sako (1972) had a recurrence rate of 20% in his series of 60 cases. Eleven of our patients showed an excellent response, but the recurrence rate could not be recorded as follow up compliance was poor.
Good healing and palliation in eleven out of thirty cases of malignancy was reported by Holden and McKelvid (1972) .In our series the cancer cases did not respond well probably due to the advanced stage of the disease presenting for treatment.
The application of low temperatures in the modern form of cryosurgery, is a simple and safe procedure. It should be utilized in Otolaryngology, being convenient for the patient and surgeon, it is also highly effective.
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