December 1988, Volume 38, Issue 12

Original Article


Muhammad Iqbal  ( Department of Surgery, Rawalpindi Medical College, Rawalpindi. )
Imtiaz Rasool  ( Department of Surgery, Rawalpindi Medical College, Rawalpindi. )
Shaukat  ( Department of Surgery, Rawalpindi Medical College, Rawalpindi. )
Habib Ur Rehman  ( Department of Surgery, Rawalpindi Medical College, Rawalpindi. )
Shims Tabriz  ( Department of Surgery, Rawalpindi Medical College, Rawalpindi. )


Over the past 3 years 52 patients with typhoid ileal perforation were treated surgically. Widal test was positive in all, and majority (42 cases) of the patients were males. Single perforation was often found in the last 20 cms of the ileum. Simple closure (31 cases) or closure with ileotransverse colostomy (21 cases) were the procedures of choice, resulting in 16.12% and 14.24% mortality in the two groups respectively (over all mortality 23.07%). A six fold increase in mortality was noted if the perforation/surgery were delayed beyond 72 hours (JPMA 38: 316, 1988).


Terminal ileal perforation leading to gener­alised peritonitis is a fairly common emergency faced by the general Surgeons in tropical countries, where salmonellosis is endemic. This abdominal emergency is associated with consi-­derable morbidity and mortality, inspite of all the advances in surgery and ancilhiary disçiplines.
Previously conservative treatment was recommended but currently early surgical inter­vention is advised. Due to this the mortality has significantly decreased. At our hospital, various procedures were adopted from simple closure of perforation to extensive resection of small and large bowel.
In the present study, patients with ileal perforation were treated with either simple closure or a simultaneous ileotransverse colostomy to see as to which procedure is best tolerated with minimal mortality in our setup.


From January, 1984 to December 1987, 52 patients with ileal perforation were admitted in Rawalpindi General Hospital. The diagnosis was established by clinical features, laboratory investigations, operative finding and histopatho­logy of the edges of perforation. Emphasis was laid on symptoms and signs of abdominal pain, fever, guarding, rigidity, distension, absent bowel sounds, fever, free fluid and obliteration of hepatic dull­ness. Investigations included Hb estimation, leucocyte count, serum electrolytes, blood urea and X-ray abdomen in erect posture. Positive widal test was considered diagnostic of typhoid infection. All the patients were stabilized prior to surgery and were operated under general anaes­thesia. A right paramedian incision was made. Pus and intestinal contents were removed from the peritoneal cavity and peritoneal toilet was carried out with normal saline.
Patients were operated upon by different surgeons and the surgical procedure included:
(a)  Simple closure following excision of edges of perforation;
(b)  Closure with proximal ileo transverse colostomy;
(c)  Resection with anastomosis and pro­ximal ileo transverse colostomy;
(d)  Resection and ileostomy and mucus fistula and Exteriorization of perforation.
Silk 2-0 was used for surgical repair. used in all the cases and abdomen in layers with vicrly number one.   Post operatively ali the patients received parenteral chloramphenicol 500 mgx6 hourly for adults and 250-500 mgx6 hourly for children under 12 years of age for a period of 7-10 days. Other additional antibiotics given were Gentam­ycine and Metronidazole.
Age and Sex
A total of 52 patients (41 males and 11 females) were operated upon. Ages of the patients ranged from 5½ years to 71 years, (Mean 25 years) with maximum frequency in 10- 30 years age group.
Signs and Symptoms
Acute generalized pain was present in all the cases while 85% complained of fever and vo­miting. Constipation was present in 48% cases. On examination all cases had abdominal tender­ness. Other signs included abdominal distension (92%), dehydration (85%), absent gut sounds (75%) and obliterated liver dullness in 58% cases.
Widal test was positive in all the cases and was taken as confirmatory evidence if the titre was higher than 1:80. Blood and stool cultures were not done in any case. Total white cell count ranged between 4200 to 16000 cmm, and that of haemoglobin from 8.6 gm to 15 gms with an average of 10 gms%.
Plain X-ray of the abdomen in erect posture was taken in all the patients, of them 38 (73%) showed gas under the diaphragm, 8 (1538%) revealed free fluid ileus.while 6 (11.53%) showed no abnormality. Histopathology of edges of per­foration confirmed the diagnosis in 42 patients.
Operative Findings and Procedures
Generalised peritonitis was noted in all the cases. About 500 ml of pus was drained in 32 cases and a litre or more in 20 cases. The site of the perforation was located between 2.5 cm to 60 cm from ileocaecal junction. Last 20 cm of ileum was the commonest site of perforation (44 patients) while perforation beyond 20 cms was seen in 8 patients. Forty one (79%) cases had single perforation, 6 had 2, 3 had 3 and 2 had 6 perforations. The size of perforation ranged from 0.5 cm to 1.5 cm and they were situated on the antimesenteric border of the ileum. The threa­tening perforation was seen in ten patients which was closed in a single layer. The operative proce­dures adopted are shown in Table 1.

Simple closure was the commonest surgical procedure. The choice of operation did not have any correla­tion with the site or number of perforation, and was entirely the choice of surgeon.
Performation Operation Interval
Mortality increased with the delay in operation after perforation. When the operation was performed within 24 hours the mortality was 11% and delay of 48 hours or over, resulted ina mortality of more  than 50% (Table II).

Morbidity and Mortality
Twelve (30.4%) patients died (Table III).

The rate of post operative complications was high because more than 50% patients suffered from multiple complications. The commonest complications were wound sepsis (75%) and bronchopneumoma (70%). Formation of a faecal fistula, however, was the most dreaded compli­cation with 100% mortality. Minimum mortality was found in simple closure (16.12%) and simple closure with ileotransversely colostomy which gave almost identical results (14.2%).


Typhoid ileal perforation is the commonest perforation seen in the tropical countries. It is more frequently seen in males with a male to female ratio of 3:1.
In the present study the perforation occurred during the second week and was preceded by a history of fever with an average duration of ten days, Abdominal pain was the commonest symptom’, and tenderness the commonest sign. The frequency of abdominal tenderness varies from 74 to 100%1-3 with a probable masking effect of extensive toxaemia causing lower incidence of tenderness. 3 Abdominal pain was reported in 81% cases in another study4. The findings of pneumoperitoneum in 73% cases and free fluid ileus in 1538% in the present study are similar to those reported by others. 5
Conservative treatment versus surgical treatment has remained a controversial subject in the past. Li6 and Dickson7 were the first to recommend surgical closure of perforation together r with evacuation of pus and faecal matter, toilet of peritoneal cavity and insertion of a drain. If perforation causes generalised peritonitis, surgery offers the best hope of survival. As 19% of the patients had multiple perforations therefore spontaneous closure seems unlikely in such cases and operative intervention is the only wayout for preventing persistent soiling of the peritoneum, which inevitably enhances the toxaemia1.
A number of surgical procedures have been described but majority of the surgeons re­commend simple closure. However, new methods and modifications have also been suggested. Kala et al8 recommended resection of the perforated ileum and end to site ileo transverse colostomy with burrying a distal stump in the caecal wall. He had a mortality of 20%. Lezarralde9 recom­mended ileotransverse colostomy and a second operation several weeks later, for restoration of continuity by end to end ileostomy, but usually two procedures are resented by the patients.Molaney10 treated 5 patients with tube ileostomy via perforation and recommended this procedure.
Peritoneal lavage with normal saline appears to minimise late intraperitoneal sepsis5. Post-operative peritoneal toilet with an inlet in the right hypochondrium and the outlet in the pouch of douglas has also been suggested’11 The solution used for irrigation was dextran with 4 grams, of chioramphenicol per litre, together with one million international units of trasylol. They.. found that the mortality was significantly reduced (3.03%). However, morbidity was as high as 60%.
Our experience is that the majority of the patients suffer from a single perforation (80%) and that the primary closure is the best procedure. The edges of perforation should be widely excised and ileum closed with 00 silk in a single layer. Eutache and Kreis’12 reported a mortality of 21% by this procedure. Vyas et al’13 recommended omentopéxy. Where marked oedema and chances of leakage are present, proximal ileo transverse colostomy is advised to decompress the ileum. In the present study both the procedures gave ahnost identical results. Eggleston and Santshi14 compared primary closure with closure plus ileo transverse colostomy, and. found no difference in mortality and morbidity in the two groups. Even if the perforations are multiple excision of edges and closure of perforation is the best and simplest procedure. Welch and Martin15 recommended resection of a small length of bowel including diseased part and a two layer end to end anasto­mosis. Other surgical procedures have not produced encouraging results and therefore are not recommended.
The mortality of typhoid perforation can be further reduced if the operation is performed as early as possible after, perforation. Prolonged perforation-operation interval accentuates the toxaemia and brings electrolyte changes. Early diagnosis of perforation and treatment is hence mandatory. In our experience, any delay beyond 48 hours increases the mortality to over 50% and so is the experience of Kapoor et al16


1  Archampong, E.Q. Operative treatment of typhoid perforation of the bowel. Br. Med. j., 1969; 3;273.
2. Karmaiker, S.R., Triwedi, D.R. and Shalerao, R.A. Perforation of the terminal ileum. Indian J. Surg.1972; 34: 422,
3. Chouhan, M.K. and Pande, S.K.Typhoid enteric perforation. Br. J. Surg., 1982; 69: 173.
4. Khan, A.S., Rukhsana and Rana, S.A. Typhoid perforation; results of surgical treatment.  JPMA., 1982; 32 :46.
5. Keenan, J.P. and Hadley, G.P. The surgical manage­ment of typhoid perforation in children. Br. J. Surg., 1984; 71: 928.
6. Li, F.W.P. Surgical treatment of typhoid perfora­tion of the intestine. Br. J. Surg., 1963; 50: 976.
7. Dickson, J.A.S. and Cole, G.J. Perforation of ter­nunalileum; a review of 38 cases 51. Br. J. Surg., 1964; 51: 893.
8. Kala, R.P., Asopa, H.S., Mathur, S.L and Atri, S.F. Resection and ileocolostomy for enteric perforation of the terminal ileum. Indian J. Surg., 1978;40 :674.
9. Uzarralde, E.A. Typhoid perforation of the ileum in children. J. Pediatr. Surg., 1981; 16 : 1012.
10. Maloney, C.T. Surgical treatment of typhoid perforation of ileum. N.Y. State j. Med., 1971; 71:663.
11. Badejo, O.A. and Arigbabu, A.O. Operative treat­ment of ayphoid perforation with peritoneal irrigation; a comparative study. Gut, 1980; 21 141.
12. Eustache, J.M. and Kreis, DJ. Jr. Typhoid perfora­lion of the intestine. Arch. Surg., 1983; 118: 1269.
13. Vyas, l.D., Purohit, M.G. and Dainany, S.B. Operative treatment of typhoid ile, al perforation with omental patch; comparative study. Br. J. Clin.Pract., 1983;37 : 367.
14. Eggleston, F. C. and Santoshi, B. Typhoid perfora­tion, choice of operation. Br. J. Surg., 1981; 68: 341.
15. Welch, T.P. and Martin, N.C. Surgical treatment of typhoid perforation. Lancet, 1975; 11078.
16. Kapoor, V.K., Chattopadhyay, T.K. and Sharma, L.K. Typhoid perforation (letter). Br. J. Surg., 1986; 73 : 79.

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