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May 1988, Volume 38, Issue 5

Letter to the Editor

NORFLOXACIN IN WOUND INFECTIONS

Sir,

We report five cases of infected wounds including Gun Shot wounds involving skin and bones treated with Norfioxacin after they became resistant to all other available antibiotics. The drugs was used on an average for ten days and the wounds healed well. NORFLOXACIN is a chemotherapeutic agent, if used in therapeutic dosage it reaches with 80% concentration in urine, and 30% is achieved in soft tissues and bones. It is basically used for UTI. The much wider spectrum of activity is advan­tageous and should make it particularly useful in therapy of complicated Urinary Tract Infec­tionsl. In our cases we have used after positive culture and sensitivity report of septic wounds and osteomyelitis resistant to other antibiotics2. Norfioxacin has superior anti pseudomonal activity. In our experience in the above mentioned five problem cases we achieved good results and even in one case bone graft was taken up successfully, who was bedridden for 02 years. Now he is ambulant.

The drug has the advantage of quick action and BD dosage.

Yours sincerely,
Rafiq Ahmad Mirza Qadir Bux Combined Military Hospital, Hyderabad (Sind).

REFERENCES

1. Haase, BA. et al. Comparative trial of Nor­ floxacin and trimethoprim-Sulphamethoxazole in the treatment of women with localised acute, symptomatic urinary tract infections and anti­ microbial effect on periurethral and fecal micro- flora. Antimicrobial Agents and Chemotherapy, 1984 ; 26:481.
2. Gilfillan, E.C. and Sabbaj, J. Norfioxacin A quinoline Carboxylic Acid Antibacterial agent with broad spectrum activity against aerobic Bacteria. Today’s Therapeutic Trends, 1985;3 : 16.

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