May 1990, Volume 40, Issue 5

Case Reports

A CASE OF ULCERATIVE COLITIS WITH AMYLOIDOSIS PRESENTING AS FEVER OF UNKNOWN ORIGIN

Javaid A. Khan  ( The Aga Khan University Hospital, Karachi. )
Wasim Jafri  ( The Aga Khan University Hospital, Karachi. )
Hizbullah Sheikh  ( The Aga Khan University Hospital, Karachi. )
Ata Khan  ( The Aga Khan University Hospital, Karachi. )

Amyloidosis is a disorder of protein metabolism which is characterized by deposition of eosinophilic material intercellularly which has characteristic ultra-structural morphology and biochemical features. Amyloidosis may be primary but more often it is secondary to various inflammatory, neoplastic and sup­purative conditions. Inflammatory bowel disease is an unusual cause for secondary amyloidosis. The incidence of amyloidosis in Crohn’s disease varies from 1-8%1,2 ; however it is extremely rare in ulcerative colitis. We describe a case which was admitted to determine the cause for fever of unknown origin (F.U.O.) which turned out to be a case of secondary amyloidosis due to ulcerative colitis.

CASE REPORT

A 37 years old lady was admitted in Aga Khan University Hospital for investigation of fever for the pastS months. The fever was intermittent ranging from 37.2°C to 38.2°C. She also complained of anorexia and progressive weight loss (25 to 30 lbs in 5 months), and dry cough and had become ammenorrhoic 3 months prior to her admis­sion in hospital. Her bowel habits were normal till 3 days before her admission, at that time she developed loose motions, the frequency of which was 2 to 3 per day. Two of  the motions contained fresh blood. There was no previous history of bowel disturbance. Her past medical history was unremarkable apart from jaundice at the age of 10. During 5 months of her illness she had received various courses of antibiotics and three weeks before her admission she was put on antituberculous treatment.

ON EXAMINATION

She was anaemic. Her pulse was 120/min and BP 100/70mm Hg. There was no jaundice or lymphadeno­pathy. She had a normal chest and cardiovascular ex­amination. Her abdominal examination showed no or ganomegaly. Rectal and vaginal examinations were nor­mal.

INVESTIGATIONS

Investigations showed hemoglobin of 8.1 g/dl, blood film showed macrocytosis and anisocytosis and red cell indices revealed a microcystic hypochromic picture. ESR was 140 mm/hour. Her blood sugar and serum creatinine was normal but serum albumin was 1.0 mg/dl. She also had prolonged PT of 20 sec. (control 13 sec). Stool analysis was positive for occult blood but stool cultures were. negative. Urine analysis showed + 3 proteinuria. 24 hour urine for protein was 4336 mg/24 hours. Urine,stool and sputum were negative for AFB. Bone marrow examination and culture was negative. Serum protein electrophoresis showed polyclonal gam­mopathy. Her chest X-ray, abdominal ultrasound, barium meal follow through and barium enema all were normal. Liver biopsy was done after correction of her coagulation profile with fresh frozen plasma. She had 2 further episodes of blood in stools therefore flexible sigmoidoscopy was performed upto 60 cms. Mucosa was found to be inflammed in patches with friability and contact bleeding, linear ulcers covered with pus were also seen, the inflammation appeared discontinuous. Multiple biopsies were obtained for histopathological diagnosis. Mucosal biopsy showed active ulcerative colitis (Figure 1).

Congostain of both hepatic (Figure 2)

and colonic (Figure 3)

biopsies revealed the presence of amyloid. The patient was treated with blood transfusion, salazopyrine and steroids. Initially she responded to treatment but later relapsed. She progressivelylost weight, continued to have diarrhoea and failed to respond to any treatment. She expired at home after 2 months of dis­charge. Because of her very poor general condition and severe nephrotic syndrome, surgery was not con­templated.

DISCUSSION

Inflammatory bowel disease (Crohn\'s disease and ulcerative colitis) may be complicated by secondary amyloidosis affecting the kidneys and rarely adrenal glands as well3. Amyloid may produce frank nephrotic syndrome and even frank renal failure4,5. Patients who die because of complications of inflammatory bowel disease, amyloidosis may be an important cause of death, it was reported as 29% in one series6. Pen-intestinal suppuration and fistulization usually precede the development of secondary amyloidosis in ulcerative colitis. Primary dis­turbed immunologic mechanism has been postulated as responsible for both enteritis and the amyloidosis in Crohn’s disease which may be true for ulcerative colitis as well. Clinical evidence of amyloidosis complicating inflam­matory bowel disease either as nephrotic syndrome, hepatomegaly or splenomegaly, constitute an indication for resection of the diseased bowel6. Mild tubular dysfunc­tion and non-specific glomerulitis has also been dis­covered at autopsy in patients with both acute and chronic inflammatory bowel disease. Hepatic amyloidosis com­plicating inflammatory bowel disease usually Crohn’s disease has been reported very rarely. Shorvan found 33 cases in literature upto 19777 and Eade found amyloid deposits in 2 of 20 liver biopsies in patients with Crohn’s disease8. Our case has demonstrated evidence of amyloidosis complicating ulcerative colitis in biopsies obtained from the colon and liver (Figure 2 and 3) although renal biopsy was not obtained but the evidence of nephrotic syndrome leaves no doubt that kidneys were also involved in secondary amyloidosis.

REFERENCES

1. Fausa, 0., Nygaard. K. and Eijo, K. Amyloidosis and Crohn’s disease. Scand. 3. Gastroenterol., 1971; 12: 657.
2. Fitchen, J.H. Amyloidosis and granulomatus ileocolitis. Regression aftersurgical removal of the involved boweL N. Engl. 3. Med., 1975; 292. 352.
3. Cbapin, LE., Scudamore, H.H., Baggenstoss, A.H. and Bargen, J.A. Regional enteritis; associated visceral changes. Gastroenterology, 1956; 30: 404.
4. Greenstein, A.3., Janowitz, H.D. and Sachar, D.B. The extra- intestinal complications of Crohn’s disease and ulcerative colitis; A study of 700 patients. Medicine, 1976; 55 : 40L
5. Wallenstein, L, Serebro, H.A., Calle, S., et al Chronic regional enteritis complicated by a nephrotic syndrome due to amyloidosis; antemortem clinical study. JAMA., 1966; 198: 555.
6. Werther, J.L., Schapirs, A., Rubinstein, 0. and Janowitz, H.D. Amyloidosis in regional enteritis; a report of five cases. Am. J. Med., 1960 29: 416
7. Shorvon, P.3. Amyloidosis and inflammatory bowel disease. Am. 3. Dig Dis., 1977; fl:209.
8. Eade, M.N., Cooke, W.T., Brooke, B.N. and Thompson, H. Liver disease in Crohn\'s disease colitis. A study of 21 consecutive patients having colectomy. Ann. Intern. Med., 1971; 74 : 518.

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