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July 1994, Volume 44, Issue 7

Case Reports

Concomitant Squamous Cell Carcinoma of the Cervix and Adenocarcinoma of the Rectum

Tugrul Aydogdu  ( Department of Oncology and Pathology, Dr. Zekai Tahir Burak Women’s Hospital, Ankara, Turkey. )
Esra Kuscu  ( Department of Oncology and Pathology, Dr. Zekai Tahir Burak Women’s Hospital, Ankara, Turkey. )
Kubilay Vicdan  ( Department of Oncology and Pathology, Dr. Zekai Tahir Burak Women’s Hospital, Ankara, Turkey. )
Gurkan Zorlu  ( Department of Oncology and Pathology, Dr. Zekai Tahir Burak Women’s Hospital, Ankara, Turkey. )
Omer Cobanoglu  ( Department of Oncology and Pathology, Dr. Zekai Tahir Burak Women’s Hospital, Ankara, Turkey. )
Saadet Cengiz  ( Department of Oncology and Pathology, Dr. Zekai Tahir Burak Women’s Hospital, Ankara, Turkey. )

Introduction

Multiple primary cancers are rare and its first descrip­tion was made by Billroth in 18791. Recently, this condition has been detected with increasing frequency2 which may be explained by improved clinical awareness, contribution of other factors including carcinogenic effect of radiation, new environmental carcinogenic factors and also increased life expectancy of cancer patients to enable them to live long enough to develop a second primary cancer1,3,4. Most secondary tumours develop after a period of time, which may last for years1,3,4. However, two or more primary malignant tumours may be found concomitantly in a patient. We report a case with concomitant squamous cell carcinoma of the cervix and adenocarcinoma of the rectum identified incidentally in an operation performed for carcinoma of the uterine cervix.

Case Report

A 47 year old woman, gravida 6, para 4, presented with 2 months history of a malodorous vaginal discharge and postcoital bleeding. On pelvic examination, an exophytic bleeding lesion measuring 1x2x1.5 cm in diameter was seen on the upper lip of the cervix. The size of the uterus and both adnexal regions were normal. No abnormality was found with digital examination of rectum. Cervical punch biopsy and endocervical curettage (ECC) was performed and pathologic diagnosis was squamous cell carcinoma of the cervix. Endocervical curettage findings were negative. After pelvic examination, colposcopic examination of cervix and vagina, colposcopically directed punch biopsy, endocervical curet­tage (ECC), intravenous pyelography (1VP), barium enema and ultrasound (USG) were done and the diagnosis was Stage I squamous cell carcinoma of cervix. She was prepared for surgery and at laparotomy, samples from para-aortic lymph nodes were obtained for frozen-section which showed no evidence of malignancy, therefore, a type 3 extended hysterec­tomy was performed. When the peritoneum of the back of the uterus was dissected, a firm mass, 2x3x3 cm in diameter was identified in the rectosigmoid region. Therefore, the patient was simultaneously operated by a general surgeon. The mass involving rectosigmoid region was resected and the frozen section showed that it was a primary adenocarcinoma of the rectum. After end-to-end anastomosis of rectum type 3 extended hysterectomy, pelvic and para-aortic lymph adenec­tomy were performed. Histopathological examination of specimen showed that adenocarcinoma of the rectum was grade 2 and invasion was limited to rectal wall with no evidence of serosal involvement, the surgical limits of the specimen were free of cancer cells. Squamous cell carcinoma of the cervixwas grade III and limited to endocervix. All of the 39 lymph nodes obtained during operation were histologically negative for metastasis. The patient had post-operative radio­therapy. She has been followed with 3 months’ intervals. Her follow-up over 30 months including pelvic examination, vaginal smear, chest film, 1W, biochemical tests for liver and kidney, USG, rectoscopy, bone scanning and computed tomography of upper abdomen and pelvis did not show any recurrence.

Discussion

Multiple primary malignant tumours in patients with cancer are uncommon with a 3-3.6% frequency seen on autopsy4-6. Although it is rare to find more than three separate primary cancers in one individual7, there were a few patients who had six or more primary cancers4-8. A review Of literature has shown that cancers in these patients were predominantly gastrointestinal in origin and most of them had a family history of cancer4,7,9. The necessary criteria for diagnosing multiple primary tumours were defined by Warrens and Cates10 which conclude that each primary tumour must present its own definitive malignant pattern, each must be distinct and the pmbabiuiy of metastasis must be excluded. Recently, multiple cancers have been identified with increasing frequency2 and this may be explained by several factors1-4. Arai et al.3 showed that there is evidence of second cancer development after radiation ther-apy for cancer of the uterine cervix. Their results suggested that there was no significant increase in the risk of second primary cancers when all sites were combined but if the assessment was done on site by site basis, significant increase was noted for the rectal cancer, leukemia and bladder cancer after radiotherapy. A significant excess of second cancers was found within the organ system within the irradiation field but not outside the field, the excess of rectum cancer began with the 2 to 5 years period after exposure and increased with time. Chemotherapy is reported to increase the risk of second cancers especially in leukemia and bladder cancers11-13. Other factors contributed to the detection of second cancers are increased clinical awareness of this condition, new environ¬mental factors and increased life expectancy of cancer patients1,3,4. To our knowledge, multiple primary cancers found concomitantly are uncommon and mostly develop after a period of time. The patient presented here does not have a family history nor a history of radiotherapy or chemotherapy and the diagnosis of cervix and rectal cancers was done at the same time.

References

1. Schwartz, Z., Ohel, G., Birkenfeld, A. et at. Second primary malignancy in endometrial carcinoma patients. Cynecol.Oncol., 1985;22:40-45.
2. Cahan, W.G. International workahop on multiple primary cancer. Introductory remarka. Cancer, 1977;40:1785.
3. Arai, 1., Nakano, 1., Fukuhiaa, K. et al. Second cancer after radiation therapy for cancer of the uterine cervix. Cancer, 1991 ;67:398-405.
4. Swaroop, V.S., Winawec, S.J>, Lightdale, CS. ct at. Six primary eancera in individuala. Report of four caaea. Cancer, 1988;61:1253-54.
5. Taylor, TV. and Torrance, B. Behaviour of multiple primary neoplaama. Br.McdJ., 1977;2:11-25.
6. Amot, R. S. and Borgea, A. Multiple inteatinal malignancy. Clin.Oncol., I 979;5:257-69.
7. Love, R.R. Small bowel cancera. B-cell lymphatic leukemia andaixprimary rancere with metaataaea and prolonged survival in the cancer family ayndrome of Lynch. Cancer, 1985;55:499-502.
8. LaFerla, 0. and Thomaon, W.O. A patient with aix primary carcinomata. Poet­grad.Med.J., 1984,60:687-88.
9. Forreat, J., Slaney, 0., Crocker, 1. et al. Multiple malignancy with a familial tendency. Clin.Oncol., 198 1;7:357-64.
10. Warren, S. and Oatea, 0. Multiple primary malignant tumour. Am.J. Cancer, 1932;16: 1358-1414.
11. Diaai, P.J. and Creasman, W.T. Advanced epithelial ovarian cancer. In clinical gynecologic oncology (S. Bircher, Ed.) St. Louia, The C. V. Moaby Company, 1989, pp. 325-416.
12. Coleman, C.N. Second malignancy after treatment of Ftodgkin’a diaeaee. An evolving picture. J.Clin.Oncot., 1986;4:82 1-24.
13. WaIl, R.L. and Clausen, KR Carcinoma of the urinary bladder in patienla receiving cyclophoaphamide. N.Engl.J.Med., 1975;293:271-73.

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