Manzoor Hussain ( Department of Ophthalmology, Shaikh Zayed Postgraduate Medical Institute, Lahore. )
Jehangir Durrani ( Department of Ophthalmology, Shaikh Zayed Postgraduate Medical Institute, Lahore. )
Comparison of results of intraocular lens implants with IOL powers obtained by Binkhorst and SRK Linear Regression formulae was done using various models and brands of intraocular lenses. Of 887 pseudophakic patients. 415 patients received IOL\\\'s with their powers calculated for planned emmetropia, by means of theoretic formula devised by R.D. Binkhorst and in the remaining 472 eyes the IOL power was calculated with the SRK Linear Regression methbd. No significant difference (P<0.05) was found between visual acuities, obtained with IOL\\\'s alone or after postoperative overcorrection of residual refractive errors between the two groups (JPMA 45:38, 1995).
Cataract is an important cause of visual impairment and blindness worldwide, Cataract surgery is effective and widely available in most industrialized countries. The removal of th; patient’s lens creates such formidable obstacles that it has been stated that the “first complication of cataract surgery is aphakia”. These cataractous lenses, thus, must be replaced with a prosthetic optical device before useful vision can be restored to the operated eye. Spectacles have been the classic and the most common method of correcting aphakia. Unfortunately, they cause visual problems that reduce patients satisfaction1. Hard and soft contact lenses may also be used after cataract extraction. They cause fewer visual problems, but many aphakic patients cannot or will not wear them2.
Recently, in a rapidly increasing number of extractions, a prosthetic acrylic intraocular lens (IOL) is being surgically implanted inside the eye. These lenses provide many advantages over spectacles and contact lenses3. To calculate the power of IOL to be implanted there are theoretical as well as mathematical formulae available.
The Binkhorst theoretical formula4 in which P indicates implant power for emmetropia; N, refractive index of aqueous and vitreous; C, estimated postoperative anterior chamber depth; L, axial length of the globe in millimeters; and K, average corneal refractive power in diopters.
The mathematical SRK Linear Regression formula5 is: IOL=A-2.5L -0.9K, where IOL= emmetropic IOL power; Athe “A-constant” of the specific IOL being used; AL=axial length of the globe in mm and K= average cornea! refractive power in diopters.
The aim of this study was to evaluate the accuracy and reliability of the two commonly employed formulae for intraocular lens power calculation (i.e. Binkhorst and Linear Regression).
Patients and Methods
We reviewed a consecutive series of 887 extracapsular cataract extractions with intra-ocuiar lens implantation per- formed between May, 1987 and July, 1992 at Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan. The history of Ophthalmic problems was recorded along with evaluation for any systemic disease. Visual acuity was tested, cover test performed and extraocular movenlents were checked. Slit lamp biomicroscopy, applanation tonometry and funduscopy were carried out Calculation of IOL power was done by feeding the average “K reading" and axial length obtained by A-scan ultrasonography using the Biophysic or the Hondex Biometer, into the latter’s build in computer. The computer had been pre-programmed for “A-constant” and anticipated A.C. depth of several models of IOLs used in the study. Binkhorst and SRK formulae were used for computations and students “t” test applied to see the difference. Extracapsular cataract extraction was carried out in a standard way. Intraocular lens was inserted usng either air or methylcellulose as a cushion. Both modified J-loop and C-loop lenses were used manufactured by Cilco, Surgidev, Domilens and AMO. Patients were discharged on the first or second post-operative day on antibiotic and steroid eye drops. The postoperative follow up was 1,2,4 and 8 weeks. Visual acuity with IOL and with pinhole was recorded at each visit Refraction was done at 8 - 10 weeks after surgery. Sutures were cut if astigmatism measured more than 2.50 diopters.
Intraocular lens implantation is at present the commonest method of visual rehabilitation after cataract extraction in the developed countries. In the past five years this has also become the commonest method for this purpose at our Institute. Successful results of IOL implantation depend partly on the ability to predict postoperative refraction with accuracy. There is increasing evidence of the value of preoperative biometry to calculate the power of an intraocular lens implant used during cataract surgery to avoid the possibility of large postoperative refractive errors associated with the use of a standard power lens as is often done when biometry is not available15. Because the power of an intraocular lens implant cannot be altered postoperatively without further surgical intervention, a reliable procedure is needed for predicting and achieving the final chosen refractive status. Calculation of the intraocular lens implant poweris stilla relatively controversial subject. Despite the availability of numerous formulae none has proven superior in all clinical situations10. This is mainly due to the presence of various specific variables, like the type of keratorneter or ultrasound equipment used and the surgical technique adopted. These formulae are either mathematical, based on theoretical optics6,7, empirical, based on statistical regression analysis of a large number of implant patients8, or a combination of the theoretical and empirical approaches9. Some authors have recommended that the ideal solution to this problem for the individual surgeon is to develop his own formula. However, not all ophthalmologists have the time or the resources to do this and hence have to depend on one of the readily available IOL calculation formulae. The purpose of this study was to evaluate the results in our patients using two different formulae (i.e. Binkhorst and SRK Linear Regression) and compare the accuracy and reliability of these two commonly employed fonnulae. The accuracy of IOL calculation may be evaluated in terms of symmetrical errors and in terms of random errors. A symmetrical type of error is found when the average refraction deviates from the expected and may be due to synmietrical errors in the measurement system or in the formula. A random error, on the other hand, results from the inevitable errors in any measurement system. Dang and Sunder11 reported a high degree of predictive accuracy to the users of the SRK-ll Linear Regression formula than the original SRK and Binkhorst II formulae. The constants used can be easily modified for the surgeon’s specific variables and thus improve its ability to predict IOL power. Retzlaff and Medford12 reported more accurate results with Regression Formula than with Theoretic Formulae. Similar results have been quoted by Tutton13. Binkhorst and Linear Regression formulae are less accurate in axial myopes14. Armstrong and Lichtenstein16 reported that the Binkhorst formula is more accurate than Linear Regression formula in eyes with high myopia. In our study data from 887 eyes with intraocular lens implants were used to compare the prediction accuracy of two different lens power formulae: Binkhorst and SRK Linear Regression formulae. No significant statistical difference was found in the postoperative visual acuities without over correction and in the residual postoperative refractive error while using the two formulae (P value >0.05 by ‘t’ test). After testing the accuracy and reliability of the two formulae it is then optional to use any of these two formulae it is then optional to use any of these two formulae for IOL power calculation. We hope that more studies inwhich the IOL power is recalculated using postoperative measurements will demonstrate that previously unexplained differences between these formulae are due to poor techniques and inadequacies in current instrumentation and that these findings will require manufacturers to upgrade the quality of the instruments to their full potential.
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