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April 1996, Volume 46, Issue 4

Case Reports

Endobronchial Tuberculosis Manifesting by Coughing Up of Bronchial Cartilage

Abdul Majeed Memon  ( Department of Medicine, Aga Khan University Hospital, Karachi. )
Anwar Shafi  ( Ziauddin Postgraduate Institute of Medical Sciences, Karachi. )
Hasina Thawerani  ( National Institute of Cardiovascular Diseases, Karachi. )

Introduction

As compared to the Tuberculosis involving the lung parenchyrna, endobronchial tuberculosis (EBTB) is less well known. The importance of endobronchial tuberculosis lies in the fact that it has varied clinical manifestations and the diagnosis can be missed at initial presentation. We describe a case where endobronchial tubereulosis manifested by expec­toration of bronchial cartilage.

Case Report

A 32 years old physician presented with a four months history of severe cough, initially dry but later on productive with copious whitish sputum, dyspnea and wheezing. The cough and dyspnea were aggravatedon lying down causing difficulty in sleeping at night. He gave no history of fever, haemoptysis or weight loss. The past medical history was insignificant and he denied any family history of tuberculosis. He did not have any wheezing spells in the past.
Physical examination revealed an apparently healthy young man with normal weight, temperature and blood pressure. There was no lymphadenopathy. Abdominal, car­diovascular and central nervous system examination were normal. The chest examination revealed moderate bilateral wheeze.
His 1-lb was 13.9 g/dl, WBC 7.7x109/L with neutrophils 72% and lymphocytes 21% and ESR 40 mmHg after the first hour. Chest X- ray, PA and lateral views did not show any infiltrative or cavitaiy lesion.
He was given bronchodilators and oral as well as inhalation steroid therapy with minimal relief of symptoms. Approximately a week later he coughed up a whitish meat like mass measuring l.5x1.0x0,6 cm in volume after which his wheezing and dyspnea subsided and he had minimal residual cough. Microscopic examination of the expectorated material revealed a crescentic rim of focally necrotic hyaline cartilage (Figure 1)

around necrotic material with partially autolysed granulomas (Figure 2),

composed of epithelioid cells admixed with few lymphocytes and occasional multinucleated giant cells (Figure 3).

Periodic acid Schiff stain was negative for fungi and Ziehi-Neelsen stain was negative for acid fast bacilli. His symptoms returned after three weeks while on bronchodilators. He again expectorated a small piece of similar material which revealed necmtic tissue on his­topathologic examination. Computerized Axial Tomographic (CAT) scan of the chest was perfonned to look for any parenchyma damage but no lesion was seen.
Fiberoptic bronchoscopv under L.A. showed partial obstruction of the left main stern bronchus and total obstruc­tionof the left upper lobe bronchus by necrotic tissue. The wall of the left. upper bronchus was completely collapsed. Bron­chiallavage was done and biopsy obtained. A biopsy of the left upper lobe showed necrotic material and bronchial washing for AFB smear was negative. A post-bronchoscopic sputum sample smear was, however, loaded with AFB. This was later confirmed by microbial culture which yielded mycobacterium tuberculosis.
The patient was started on INH, Rifampacin, Etbambu­tol and Pyrazinamide. He is asymptornatic on these medica­tions and has stopped coughing. No further expectoration of necrotic material has occurred since six months.

Discussion

Endobronchial tuberculosis can be seen in both primary as well as post-primary tuberculosis1. Because of its location and the fact that it can present without any abnormality on chest x-ray, it constitutes a definite diagnostic problem2. A shift in age distribution, from younger to older age group after the advent of effective anti-tuberculosis chemotherapy3, in western countries adds another dimension of difficulty for the physicians in diagnosing this disease.
Although, many cases of endobronchial tuberculosis have been reported over the years, coughing tip of a piece of bronchial cartilage has not been reported. A medline search did not uncoverany reported case in the last 30 years. In adults bronchial lesions are most commonly secondaiy to repeated implantation of tubercle bacilli from an adjacent parenchymal source. On rare occasions small portions of bronchial wall may be sloughed off.
Early diagnosis of endobronchial tuberculosis is of paramount importance keeping in mind the fact that serious complications or even death may result due to missed or delayed diagnosis4. Diagnosis is usually delayed because endobronchial tuberculosis can masquarade as different dis­ease. It can present as obstructive airway disease2,5. In elderly patients, it can simulate lung cancer especially on visual appearance at bronchoscopy6. A chest X-ray showing unilat­eral obstructive emphysema may also be a presenting feature7.
Traditional methods like chest X-ray and sputum tests for acid fast bacilli employed in the diagnosis of pulmonaiy tuberculosis may not be very helpful as endobronchial tuberculosis may be present in the absence of chest X-ray abnormality and a negative AFB smear8. It has been shown that sputum AFB smear may be negative in 85% of cases of endobronchial tubervculosis3. Although in our case the simple sputum test clinched the diagnosis.
Fiberoptic bronchoscopy has proved to be a very useful procedure not only from the diagnostic point of view but also by virtue of its value in disease management and follow-up5. However, in our case, the histopathologic studies of broncho­scopic biopsy did not reveal any acid fast bacilli and bronchial washing was also negative for acid fast bacilli. Bronchoscopy has been shown to relieve atelectasis with improved success of treatment with anti- tuberculosis drugs9. It can also be used to evaluate the response of endobronchial tuberculosis to medi­cations10. CT scan can also be employed to assess the degree of endobronchial invèlvernent2. In our case CT scan was, however, normal.
Treatment consists of the standard anti-tuberculosis drugs, which generally give good results10,11,13, There is no documented role of corticosteroids in the treatment of endobronchial tuberculosis12.
The most common complication of endobronchial tuberculosis is residual bronchostenosis which can occur despite properanti- tuberculosis chemotherapy4,11. It has been reported that some degree of bronchial stenosis is present in greater than 90% of patients with endobronchial tuberculo­sis14. In some cases stenosis can be severe and may require surgical treatment11. Surgical treatment consists of sleeve resectionofthebronchus and lobectomies11,15. Otherforms of treatment for bronchial stenosis secondary to endobronchial tuberculosis include balloon dilatation and laser photoresec­tion2. A case has been reported which was successfully treated with self expanding metallic stent14.
The value of careful sputum study for acid fast bacilli is probably under stress. In a country like ours, with non-availability of bronchoscopic facility at most institutions, the need for cost effective tests cannot be over emphasized. Pulmonary tuberculosis is very common in our daily practice, all we need to do is look for more patients with endobronchial tuberculosis and help prevent major complications.

References

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2. Khan. J.A., Islam, N., Akhter, J. et a!. Endobronchial tuberculosis simulating bronchial asthma. J. Pak. Med. Assoc., 1994;44:49-50.
3. Mary, S.M, Lam, W.K. and Mok, C.K. Endobronchial tuberculosis revisited. Cheat, 1986;89:727-30.
4. Chang, S.C., Lee, P.Y., Perng, R.P. The value of roentgenographic and fiberobronchoscopic findings in predicting out come of adults with lower lung fie!d,T.B.Arch.Intem. Med., 1991;151:1581-83.
5. Abdulla, F and Dietrich, K.A. Endobronchial tuberculosis manifested as obstruc­tive airway disease in a 4 months old infant. South Med. J., 1990;83: 715-17.
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10. Kim, Y.fl., Kim, H.T., Lee, KS. et al. Serial fiberoptic observations of endobronchial tuberculosis before and early after anti-tuberculosis chemother­apy. Chest, 1993;103:673-7.
11. Tse, C.Y. and Natkunam, R. Serious sequelae of delayed diagnosis of endobronchial tuberculosis. Tubercle, 1988,69 213-16.
12. Chan, H.S., Sun. A. and Hoheiscl, GB. Endobronchial tuberculosis - Is corticosteroid treatment useful? A report of 8 cases and review of literature. Postgrad. Med. 3., 1990;66:822-6.
13. Van, D., Brande, P.M., Van-De, M.F. et al. Clinical spectrum of endobronchial tuberculosis in elderly patients. Arch. Intern Med., 1990;150:2105-8.
14. Han, J.K., Im. JO,, Park, J.H. et al. Bronchial stenosis due to endobronchial tuberculosis. Successful treatment with self expanding metallic stent (AiR) Am. J. Roentgenol.. 1992;159:971-2.
15. Watanabe, Y., Murakami, S. and Iwa, T Bronchial stricture ducto endobronchial tuberculosis. Thorac. Cardiovaac Surg., 1988:36:27-32.

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