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November 1998, Volume 48, Issue 11


Second Malignancy - A Chance or Probability!

Itrat Mehdi  ( Pakistan Medical Research Council, PMRC Research Centre, Jinnah Postgraduate Medical Centre, Karachi. )

With the decline in infectious diseases, cancer is becoming a major health problem in the developing world with its morbidity, complications, and mortality. Number of cases identified and reported are increasing due to better health education, awareness, improving diagnostic facilities and availability of these facilities to a greater proportion of the population.
The last two decades have witnessed significant and remarkable advancement in terms of screening1, early detection, prevention2 and treatment of cancer. A number of effective cytostatic and cytotoxic agents are becoming available which have better tolerability, biOavailability and utilization3. Surgery has become more applicable with early detection at a stage of local and regional disease. The impact of newer iniinunomodulators, genetic manipulations, growth factors, receptor amplification/downregulation, biological response modifiers, endocrine manipulation and many newly emerging modalities are encouraging but need to be evaluated in detail to be inducted in clinical practice4-6. The cumulative effect of all these advancements are a higher cure rate, a prolonged disease free survival, a more sustained remission and an improved life expectancy.
The improved life expectancy of cancer patients has brought newer dimensions into the focus. A new dimension worth mentioning and seeking attention is development of a second and a third malignancy7, of a different histology at a different site/organ, subsequently over the years. This risk is ten times higher than normal age matched controls8. The SEER study (Surveillance, epidemiology and end results data) showed 1168, 910 tumours in 1092, 234 patients indicating 76,696 patients (7.0%) having more than one malignant tumour9.
The development of a second malignancy can be spontaneous or triggered by cytostatic/cytotoxic chemotherapy10, radiation therapy12 immunotherapy13-16 or endocrine manipulation17. These may have a direct effect or mediated through genetic alteration. The genetic makeup of certain individuals make them more susceptible to development of either first or subsequent malignancy. This is also explained by the close association of genetic diseases with tumours18 The precise mechanism by which second cancer develops is not clear but exposure to a shared mutagen, abnormalities in oncogene activation and aberrant expression of tumour suppressor genes are implicated19,20. Environmental and life style factors like smoking are also believed to be contributory in development of a subsequent malignancy21,22. No definite etiologic factor or mechanism could be implicated in a number of cases of second malignancies23. Second malignancy is commonly associated with survivors having a haematologie malignancy in childhood24. Commonly found second malignancies are osteosarcoma, soft tissue sarcoma, breast cancer, leukaeniia. thy roid cancer, CNS tumours, mclanoma, non- melanomatous skin cancers, renal cancer and lymphomas25,26. Unusual tumours like squamous cell carcinoma, as young as in 12- 18 years old children, are also reported as second nmlignancy27,28, The time interval elapsed between the first malignancy and the development of a subsequent malignancy is highly variableand has been reported as short as three years to as long as over thirty years26,29-32.
The risk of a second malignancy varies between 0-15% at 10 years and 5-21% at 20 years after first malignancy21,24,29,33-35. A much higher risk of 22% at 5 years for a second (almost always fatal) malignancy, is being reported with head and neck cancers treated with conventional modalities36. The elevated risk of a second cancer remains relatively constant over tune, but the absolute risk increases substantially24. It is reported that patients with stage 111 andIV disease have an increased risk of second malignancy regardless of age suggesting the significance of tumour related biological factors37. A further impairment in patients immune status is reported after a diagnosis of second malignancy, making them even more susceptible to all sorts of infection and further malignancies37,38.
The persons or families with genetic diseases are at a higher’risk. They need to be identified and a long follow up is indicated. A better understanding of environmental and life style associated risk factors and their possible influences is indicated. Very unusual tumours can develop at unusual age and it should not be overlooked. The tumour pairs which are closely related should be identified for further workup. The tinie interval between the first and subsequent malignant tumours can not be predicted so continued surveillance of long term survivors of childhood cancer is stressed and descriptions of unexpected tumour pairs may target families for studies on genetic abuormalities23. Second malignancy is almost always fatal so its early recognition is highly desirable. Most patients in the developing world are diagnosed at stage III or IV, having a much higher risk of subsequent cancer development. Late diagnosis and treatment makes very few survive long enough to have a second neoplasin, but with
better diagnosis and treatment there is going to be a greater number of cases of second malignancies.


1. Brawicy OW, Prorok PC, Gohagan 3, et al. Principles of cancer screening, In: Cancer treatment. Ed. Haskell CM, Fourth edition, Philadelphia. WB Saunders 1995, pp. 14-17.
2. Meyskens FL. Principles of cancer prevention, In: Cancer Treatment Ed. Haskell, CM. Fourth edition, Philadelphia, WB Saunders, 1995, pp. 10-13.
3. Haskell CM. Principles of cancer chemotherapy, In: Cancer treatment, Ed, Haskell CM. Fourth edition. Philadelphia, W13 Saunders, 1995, pp. 31.56.
4. Quan WDY, Mitchel MS. Principles of biologic therapy, In: Cancer treatment. Ed. Haskell, CM. Fourth edition, Philadelphia, WB Saunders, 1995, pp. 57-68.
5. Kouides PA, DiPersio IF. The haematopoietic growth factors In ‘Cancer treatment’ Ed. Haskell CM Fourth edition, Philadelphia, WB Saunders, 1995, pp. 69-77.
6. Radford DM, Fair K, Thompson AM, et al. Allelic loss on a chromosome 17 in ductal carcinoma in situ of breast. Cancer Ret,, 1993;53:2947-49.
7. Robinson BA, Coils, BM, Fitzharris BM, et al. Second malignant neoplasms in patients with Hodgkin’s disease. Aust. N.Z.J. Med., 1994;24:368-73.
8. Cohen ME, Duffner PK. Long-term consequences of CNS treatment for childhood cancer, Part I: Pathologic consequences and potential for oncogenesis. Pediatr. Neurol., 1991 ;7: 157-63.
9. Percy C, Young JL, Muir C, et al. Introduction. Cancer, 1 995;75 (Suppl) 1 40-46
10. Travis LB. Curtis RE, Glimelius B. et al. Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkin’s lymphoma. J. NatI. Cancer. Inst., 1995;87;524-30.
11. Kroll SS, Woo SY, Santin S, et al. Long-term effects of radiotherapy administered in childhood for the treatment of malignant disease.s Ann. Surg. Oncol., 1994;1473-79.
12. Non D, Merimsky 0, J3atata M, et al. Postoperative high dose-rate intravaginal brachytherapy combined with external irradiation for early stage endometnal cancer: a long term follow-up. Int. J. Radiat. Oncol. Biol Phys., 1994;30:831-37.
13. Spielberger RT. Mick R, Ratio RJ, et al. Interferon therapy for hairy cell leukaemia. Leukaem ía Lymphoma, 1994; 14(suppl I ):89-93.
14. Araid S, Lewis D, Bezwoda WR. Kaposi’s sarcoma after alpha- interferon treatment for HIV-negative 1-cell lymphoma. South Afr Med. 3., 1993;83:430-31.
15. Golomb HM, Ratain MJ. Mick R, et al. Interferon treatment for hairy cell leukaemia: An update on cohort of 69 patients ‘treated from 1983.1986. Leukaemia, 1992;6:1177-80.
16. Michael, LB, Julia AC. Uterus - Gynaccologic turnours: In: Cancer treatment. eds. Charles, MH, Jonathan SB. 4th edition, Philadelphia, WB Saunders, 1995, pp. 675-88.
17. Salve I, Urban C, Haas OA, et al. Acute megakaiyocytic leukaernia in children. Clinical,’ immunological and cytogenetic findings in two patients. Cancer, 1991;68:2266-72.
18. Pandha HS, Waxman J. Multiple primary cancers in association with prostate cancer. Cancer Surg., 1995;23 :235-46.
19. Russo, CL, Mcintyre J, Goorin AM, et al. Secondary breast cancer in patients presenting with osteosarcoma possible involvement ofgermline p53 mutations. Med. Pediatr. Oncol., 1994;23:354-5 8.
20. Reynolds W, Firkins R, Aguiar S. Primary cancer of the head and neck Iowa Med., 1993;83:63-5.
21. Neugut Al, Murray T, Santos J, et al. Increased risk of lung cancer after breast cancer radiation therapy in cigarette smokers. Cancer, 1994;73 (6): 1615-20.
22. Blatt 3, Olshan A, Gula MJ, et al. Second malignancies in very- long-term survivors of childhood cancer. Am. J. Med 1992;93:57- 60.
23. Robison LL, Mertens A. Second Lumours after treatment of childhood malignancies. Hematol.Oncol. Clin. North. Am., 1993;7:401-15.
24. Smith MB, Xue H, Strong L, et a! Forty year experience with second malignancies slier treatment of childhood cancer: Analysis of outcome following the development of the second malignancy. J. Pediatr. Surg., 1993;28: 1342-49.
25. Grau JJ, Estape J, Alcobendas F, et al. Positive results ofadjuvant mitomycin-C in resected gastric cancer: A randomised trial of 134 patients. Eur. J. Cancer. 1993;29A:340-42
26. Morehead 3M, Parsons DS, McMahon DP. Squamous cell carcinoma of the tongue occurring as a subsequent malignancy in a 12-year old acute Ieukaemia survivor. Int. J. Pediatr. Otorhinolaryngol., 1993 ;26:89.94.
27. Morland BJ, Radford M. Cutaneous squamous cell carcinoma following treatment of acute lymphoblastic leukaemia. Med. Pediatr. Oncol., 1993.21:150-52.
28. Hartley AL, Birch JM, Blair V, et al. Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood. Med. Pediatr. Oncol., 1994:22:318-24
29. Rogers DA, Lobe TE, Ran EN, et al. Breast malignancy in children. 3. Pediatr. Surg., 1994;29 48-51.
30. Hut PK, Tokunaga M, Chan WY, et al. Epstein-Barr virus associated gastric lymphoma in Hong Kong Chinese. Human Pathol., 1994;25 :947-52.
31. lkeda T, Sekiguchi C, Shimamura K, et al. Breast cancer developing after chemotherapy for osteosarcoma A case report. Jpn. J. Clin. Oncol., 1991,21:444-46.
32. Giachetti S. Raoul Y, Wibault P. et al. Treatment of stage I testis seminoma by radiotherapy: Long-term results - A 30 year experience. Int. J. Radiat. Oncol. Biol. Phys., 1993;27:3.9.
33. Hunger SP, Link MP, Donaldson SS. ABVD/MOPP and low-dose involved-field radiotherapy in pediatric Hodgkin’s disease: The Stanford experience. 3. Clin. Oncol., 1994;12:2160-66.
34. Frassoldti A, Lamparelli T, Federico M, et al. Hairy cell Ieukaemia: A clinical review based 00725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative group for hairy cell Ieukaemia. Leukaemia lymphoma, 1994;13:307-16.
35. Schwartz LH, Ozsahin M, Zhang GN et al. Synchronous and metachronous head and neck carcinomas. Cancer, 1994;74:1933-38.
36. Rodriguez MA. Fuller LM, Zimmerman SO, et al. Hodgkin’s disease: Study of treatment intensities and incidence of second malignancies Ann Oncol., 1993;4:125-31.
37. Baxevanis CN, Reclos GJ, Gritzapis AD. et al. Comparison of immune parameters in patients with one or two primary malignant neoplasms. Nat. Immun., 1993;12:41-49.

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