M.Khan ( Department of Anaesthesiology, The Aga Khan University Hospital, Karachi )
M.Q.Hoda ( Department of Anaesthesiology, The Aga Khan University Hospital, Karachi )
Sacrococcygeal teratoma (SCT) is the most common congenital neoplasm of newborn with a reported incidence of 1 in 35000 live births.1-3 The first large series of infants and children with SCT was reported by Gross et al.4 They recommended complete surgical excision of tumour enbloc with the coccyx, which remains the treatment of choice today.
Clinical reviews of SCT include several mortalities due to exsanguinating hemorrhage during surgery.5-9 No study has focused on the complications occurring due to electrolyte imbalance in patients with bleeding problems, associated with these neoplasms.
We are reporting a case of neonate who was operated for excision of SCT, had preoperative coagulopathy and bleeding into the tumour. This neonate had intraoperative prolonged Q-T interval on ECG followed by cardiac arrest, and was resuscitated successfully.
Fifteen hours old, 2.7 Kg, full term, normally delivered male neonate who was otherwise active and moving all four limbs, was presented in emergency, with a single huge mass approximately 14 x 15 centimeters extending on to both buttocks (Figures 1 and 2). Tumour was generally cystic in consistency but firm at places with breaching epithelium underlying hemorrhage and echymosis. Preoperative investigations showed Haemoglobin 16.0 gm/dl, Haematocrit (Hct) 47.6, Platelets 96 x 109/lit, prothrombin time 16.3 seconds (control 12 Seconds), activated partial thromboplastin time 62 seconds (control 30 Seconds) with INR 1.6, magnesium 1.5 meq.lit (1-2 meq.lit), Calcium, 8.2 mg/dl (10mg/dl) Phosphate 9.8+ mg.dl (4.4 - 6.6 mg.dl), Sodium 132 mmol.lit, potassium 4.8 mmol.lit and Lactic Dehyodrogenase (LDH) 2735 IU.lit (253 - 548 IU.lit). In next 12 hours patient dropped his Hemoglobin from 16 gm. dl to 12.3 gm.dl and Hct 37.0, which was replaced with packed cells and coagulation was corrected prior to surgery by Fresh Frozen Plasma (FFP). Surgery was performed 27 hours after delivery. Inhalational induction was done with Sevoflurane, Atracurium was used as muscle relaxant and Fentanyl as analgesic. Intraoperative monitoring included ECG, heart rate, noninvasive blood pressure, End-tidal CO2, Pulse oximetry , temperature, and oesophageal stethescope. Surgery lasted for about two hours in prone position. Intraoperative blood loss was approximately 135 ml. which was replaced by 120 ml.of packed cells, 50 ml. of FFP and 50 ml. of crystalloid. Near the end of surgery, the patient developed prolonged Q-T interval on ECG followed by ventricular tachycardia. The situation was managed immediately by turning the neonate in supine position and external cardiac massage was started. During CPR, he received adrenaline, bolus of normal saline and calcium gluconate. Normal sinus rhythm with good cardiac output was reestablished within 5 minutes. In the immediate post resuscitation period, he developed seizures activity for which he received valium and was loaded with phenytoin sodium. He was electively ventilated in Neonatal Intensive Care Unit (NICU) for 24 hours and then extubated successfully. Post extubation the patient remained stable with no obvious neurological deficit and was discharged on the eighth postoperative day.
Blood sample which was taken in the immediate post resuscitation period and sent for laboratory investigation showed hypocalcemia (Table) despite of calcium gluconate administration during CPR.
Figure1. A2.7 kg male,nenoatewith 14 x 15 centimeters sacrococcy treratoma
Figure2. Nenorate after operative reomval of tumor as in figure 1.
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