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Towards Safe Injection Practices in Pakistan

Naveed Zafar Janjua  ( Department of Community Health Sciences, Aga Khan University, Karachi,Pakisian. )

Aamir Javed Khan  ( Birmingham AL, United States, Center for Injection Safety, Indus Hospital, Korangi Crossing, Karachi, Pakistan. )

Arshad Altaf  ( Pakistan HIV/AIDS Surveillance Project (HASP), Karachi, Pakistan. )

Khabir Ahmad  ( Canadian International Development Agency (CIDA) and Department of Surgery, Aga Khan University, Karachi, Pakistan. )

November, 2006


Injection overuse and unsafe injection practices in Pakistan require urgent attention because they are driving the hepatitis B and C epidemics in the general population. This paper presents an overview of injection safety in Pakistan, and discuss measures taken by the government to address these public health problems. Several studies have demonstrated that reuse of injection equipment is common, and that unsafe injections arc responsible for more than half of the hepatitis B and C infections in the country. An average of 13.6 therapeutic injections are received per person per year. based upon studies in Sindh province. There has been a greater recognition among government policy makers of the growing burden of hepatitis B and C over the past few years. The Prime Minister’s Program for Prevention & Control of Hepatitis established in 2005 has institutionalized injection safety within the Ministry of Health, but the control of the hepatitis B and C epidemics in Pakistan demands a far more aggressive and innovative response focused on preventing unnecessary and unsafe injections.
Unsafe Injection Practices in Pakistan
Investigations of clusters of hepatitis C virus (IICV) infections in a town in Punjab province and a pen-urban community in Karachi revealed the reuse of glass and plastic syringes by unqualified and qualified practitioners as a major factor behind the occurrence of these outbreaks.1,2 Studies from other parts of Pakistan have similarly idcntificd unsafe injections in health care settings as the major risk factor for hepatitis B virus (HBV) and HCV infections.3-6 Case-control studies have shown that more than 50% of HBV and HCV infections were attributable to unsafe injection practices.5,6
A study in a pen-urban community of Karachi in 1995 reported a very high proportion (94%) of syringe reuse.1 More recent reports indicate that half of all injections are provided with a syringe of uncertain sterility.7,8 A population based study in Sindh province in 2001 reported 13 injections per person per year, most of which (95.6%) were unnecessary.7,8 Most of these injections (94%) were provided for therapeutic purposes. and the excluded injections received for vaccinations or insulin replacement.8 Therapeutic injections in Sindh are mostly provided at general practitioner(GP) clinics (63%) and arc most frequently administered by unqualified drug dispensers (75%) at these clinics.8
An important piece of information in developing prevention strategies is to understand what drives injection overuse in Pakistan. Studies have found that low awareness in population about the risks associated with injections, belief in efficacy of injections and the quickness of relief, and private practitioners’ economic incentives and a misperception on their part that patients prefer injectable medications arc major drivers in injection overusc.9,10 Economic incentives also drive injection reuse, thus highlighting the important role of reuse prevention injection devices.8 A simple awareness campaign has been found effective in reducing the reuse of injections but not their overuse.11 An interactional group discussion strategy between practitioners and patients found to successfully reduce equipment reuse and overuse of injections in Indoncsia was also successfully repeated in Karachi.12,13 The practicality of scaling up such an intervention remains to be demonstrated.
A consequence of injection overuse and reuse is the production of a large amount of sharp waste and a higher risk of injuries to health care workers and the general populaüon. Sharp waste handling and its disposal was found to be inappropriate in GP clinic settings in studies in Punjab and Sindh provinces.14,15 Appropriate sharp waste disposal presents many challenges. System for sharp waste management arc mostly nonexistent in the GP clinic setting or even at higher level facilities. When and where sharp waste boxes are available (such as through the immunization program), these are not always used for the disposal of syringes (Figure).

Inappropriate disposal opens additional avenues for sharp injurics to health workers and to the general population.
Most health care workers arc reported to know very little about bloodborne pathogens and this poor knowlcdgc is a predictor for the lack of use of universal precautions16 Studies have reported high frequency of sharp injuries. Health care workers at public facilities reported an average of 4 needlestick injuries during the past year.17

Table summarizes injection practice indicators in Pakistan.
Current Initiatives for Achieving Injection Safety
Studies have found that interventions to achieve safe injection practices are successful and highly cost effective.18 Such interventions are likely to reduce the burden of disease and health related costs associated with unsafe injections. Evidence of unsafe injections and advocacy safe practices has heightened the awareness of policy makers in Pakistan, which in turn has prompted the government to take action towards promoting Injection safety. The following highlight rcccnt progress made by the Ministry of Health:
Legislation on quality of Syringes
A WHo funded assessment of syringe quality in Pakistan in 2004-2005 concluded that only two companies market syringes that meet ISO standards for packing and labeling. As long as there are other syringe manufacturers that meet some (but not all) of the ISO standards, the public’s right to a quality syringe will remain elusive. Furthermore, illegal reprocessing for repackaging may still occur in Pakistan. The study recommended that this issue should be addressed through the formulation of a National Regulation for disposable of medical devices that would make it mandatory o enforce international quality standards. The Ministry of Health (Moll) responded by formulating draft legislation that was shared widely with health programme managers. the industry, and consumer right organizations. The bill is currently (late 2006) with the National Assembly following approval by the MoH and the Prime Minister’s cabinet.
National Injection Safety Policy
The Expanded Programme on Immunization (EPI)
Ministry of Health (MoH), Government of Pakistan in collaboration with several stakeholders organized a seminar in August 2004 to discuss available evidence on injection safety. develop a National Injection Safety Policy and outline a plan of action. The event achieved its stated objectives and was successful in coming up with a National Injection Safety Policy.
Prime Minister’s Programme for Prevention and Control of Hepatitis
The government launched this initiative in 2005 with the goal of “a 50% reduction in viral hepatitis prevalence by 2010”. The program does not specifically target the wide availability and overuse of injectable drugs, nor does it propose to test specific safe injection interventions among GPs in the private sector where most of the reuse occurs. Furthermore, resources and efforts to promote injection safety will have to compete with many of the other objectives of this programme, including establishing laboratory diagnostic facilities and pros’ idi ng interferon treatment for a limited number of persons infected with HCV at 60 health care facilities across the country.
Future Directions
The Prime Minister’s Programme is an important step towards institutionalizing hepatitis B and C prevention within the public sector. To increase the likelihood of success in meeting its stated goal, we recommend the implementation of the following specific activities by the Prime Minister’s Programme:
Behaviour change to promote safe injection practices
A focused behaviour change and communication (BCC) strategy for health care providers and their clients in the public and private sectors is essential for success. A BCC strategy for injection safety has already been designed by the World Health Organization Safe Injection Global Network (SIGN) and should guide this effort . Much work needs to be done in finding ways for scaling up interactional group discussions (IGD) interventions to the district, provincial and national levels. In this case, bodies such as the Pakistan Medical Association (PMA) can play a pivotal role. GPs who participate in IGDs implemented through such associations arc likely to communicate the message to fellow practitioners. This may have multiple benefits; remove misconceptions among GPs about patients’ preference for injectable drugs and allay fears of losing patients if they are not prescribed injections. Reaching a consensus to use a new syringe for every injection and to decreasc the use of unnecessary injection among GPs in a locality (e.g. town, district) under the umbrella of an organization such as the PMA would help practitioners accept and adopt safe injection practices. A similar strategy has previously worked for achieving reductions in anti- motility drugs prescription for childhood diarrhea. The behaviour change strategy should be inclusive and should actively involve unqualified practitioners. Health care provision by unqualified practitioners is considered illegal although these cater to a large number people in remote and rural areas where the population does not have access to qualified practitioners.19 Furthermore, their unsafe injection practices do not differ much from the practices of qualified practitioners.14 At least in the context of unsafe and unnecessary injections, we need not differcntiatc between these two groups and should engage both in injection safety activities.
Supply of Injection Equipment
The prevention of injection equipment reuse is impossible in the absence of an adequate supply. More than 80% of injections in Pakistan are provided by the private sector andmost injection equipment is paid for by patients even in public sector settings.8 Injection devices with reuse prevention features like auto- disable (AD) syringes can achieve significant reductions in reuse in health care facilities where reuse is driven primarily by economic incentives, such as GP clinics. The unit price for syringes is a critical factor in maintaining adequate supplies within government settings as well as in the private sector. Legislation in this regard should continue to be supported by government, manufacturers and advocacy groups. Partnerships between industry and governments can play a major role in providing these devices at an affordable price and assist with the phase-out of conventional devices from the market, beginning with those that do not meet existing ISO standards of manufacture. The likely role of government is to set the policy of reuse prevention devices use at all health care facilities and to provide incentives to manufacturers in the form of tax subsidies to lower initial cost. The manufacturers must actively work to make these syringes available at the price of conventional device.
Sharp Waste Disposal
Sharp waste disposal is a major component of the Prime Ministers Programme, which includes provision of incinerators at the district level. There arc many important challenges for this approach to work. The feasibility of providing incinerators at a central place can bc learned from the experience of the Karachi City Government. Baseline surveys must guide the Ibrmulation of appropriate strategies for each district. The location of the incinerators is also crucial in terms of distance from health facilities and prevention of population exposure to the toxic chemicals produced during incineration. Usc of inexpensive technology like geographic information system (GIS) with locations for clinics population density and road infrastructure can prove vcry valuable in planning the location and future opcrations of incinerators. Districts Health Officers may not know the exact number of clinics nor the amount of waste generated from them and a registration system of clinics would be helpful for waste disposal planning. While investing in incinerators at this stage helps address thc problem of sharp waste disposal, we should also be concerned about the environmental problems associated with them and should explore environmentally sustainable choices. Pilot studies for the safely and feasibility of removing needles and recyclable components could be explored to reduce the burden cm incinerators.


Unsafe injcctions remain a major risk to public health in Pakistan, even though studies conducted more than a decade ago implicated them as the driving force behind ‘the hepatitis B and C epidemics in the country. The government has previously adopted limited interventions driven by donor demands, such as the GAVImandated use of AD syringes for new vaccines and sharp disposal in the Expanded Programme on Immunizations. A national initiative launched by the government in 2005 seeks to reduce the prevalence of viral hepatitis. but the program risks being minimally effective in the absence of specific prevention strategies focused on unsafe injections. Diluting resources and efforts by integrating curative care services in a prevention program is counterproductive, primarily because most new HBV and HCV infections continue to be attributable to unsafe injection practices. Continued research is needed to methodologically develop and test sound interventions based on theories of behavior change to achieve reduction in injection use and reuse of injection equipment, particularly among GPs and their clients. Readily available and affordable reuse prevention devices arc most likely to impact injection reuse, health worker safety. and injection waste management. Important issues such as the sustainability and coverage of operations need to be resolved in discussion with the future consumers of the proposed sharp waste disposal system.


1. Luby SP Qammddin K. Shah AA. Omair A. Pahsa 0. Khan AJ. McCormck JB, Hoodbhouy F. Fasher4foch S. The rebtionship betveien therapeutic injections and high prevalence of hepatitis C nkcuon in Ilafizabod. Pakistan. pidemiol infect 1997; 119: 349-56.
2. Khan AJ, Luby SR Fikrce F. Karim A. Obaid S. DclbwjL, S. Mirza S. Matik T. Fisher Hoch S. McCormick iB. Unsafe injections and the trdnsmission of hepatitis B and C in a periurban community in Pakistan Bull World Health Organ 2000; 78: 956-63.
3. Akht.ar S. Younus M. Adil S. Hassan F. iafri Sli. Epidemiologic study of chrornc hepatitis B virus infection in male vohintcer blood donors in Karachi. Pakistan. BMC Gastroenterol 2005: 5: 26.
4. Akhtar S. Younus M. Adil S. Jafri SH. Hassan F. Hepatitis C virus Infection in asymptomatic male volunteer blood donors in Karachi. Pakistan. J Viral Hepat 2004; 11:527-35.
5. Bari A. Akhcar S. Rahbar MH. Luby SP, Risk factors for hepatitis C virus infection in male adults in Rawalpindi.Islamabad, Pakistan. Trop Med Int Health 2001: 6: 732-8.
6. Usman HR. Akhtar S. Rahbar MH. Hamid S. Moattar T, Luby SP, Injections in health care settings: a risk factor for acute hepatitis B virus infection in Karachi. Pakistan. Epidemiol Infect 2003: 130: 293-300.
7. Janjua NZ, Akhtar S. Hutin YJ. Economc burden of unnecessary Injections in Pakistin. AIDS 2006 XVI International AIDS Conference. Toronto. Canada: lnternational AIDS Society. Geneva. 2006: TUPE0504.
8. Janjua NZ. Akhtar S. Hutin YJ. Injection use in two districts of Pakistan:
implications for disease prevention. Int J QuaI Health Care 2005; 17: 401-8.
9. Janjua NZ. Hutin YJ. Akhiar S. Ahmad K. Population beliefs about the efficacy of injections in Pakistans Sindh province. Public Health 2006: 20: 824-833.
10. Altaf A. Fatmi Z. Ajmal A, Hussain T. Qahir H. Agboatwalla M. Determinants of therapeutic injection overuse among communities in Sindh. Pakistan. J Ayub Med Coll Abbouabad 2004; 16: 35.8.
11. Luby S. Hoodbhoy F. Jan A. Shah A. Hutin Y. Long.term improvement in unsafe injection practices following community intctveniion. Int J Infect Dis 2005; 9: 52-9.
12. Agboaiwalb M. Hutin Y. Luby S. Mussarat A. A pilot intervention to improve injection practices in the informal private secior in Karachi, Pakistan. Abstract #AC 112. Second International Conference on Improving Use of Medicines (ICIUM). Chiang Mai, Thailand. 2004.
13. Hadiyono .JE Suryawali S, Danu SS. Sunartono. Santoso B. lnteracional group discussion: results of a controlled trial using a behavioral intervention to reduce the use of injections in public health facilities. Soc Sci Med 1996; 42: 1177-83.
14. Janjua NZ, Akhtar S. Hutin YJ. Economic burden of unnecessary Injection in Pakistan. Report Submitted to WHO. Karachi: Aga Khan University. Pakistan / World Health Organization. Geneva. 2005.
15. Janjua NZ. Injection practices and sharp waste disposal by general practitioners of Murree. Pakistan. J Pak Med Assoc 2003: 53: 107.11.
16. Janjua N. Poor Knowledge - predictor of nonadherance to safety precautions for blood borne pathogens at first level care facilities. Global Health Education Consortium (GHEC) Conference- Crossrocids in Global Health: The Dual Challenge of Infections and Chronic Diseases. Toronto: Global Health Education Consortium (GIIEC) and Centre for International Health at University of Toronto (CIH). 2006.
17. Mantel C. Survey on the safety of injections in Pakistan. Assignment report, 17 May 2002.-Islamabad: Ministry of Health. Govmment of Pakistan. 2002.
18. Dziekan G. Chisholm D. Johns B. Rovira J. Hutin YJ. The cost-effectiveness of policies for the safe and appropriate use of injection in healthcare settings. Bull World health Organ 2003; 81: 277-85.
19. Janjua NZ. Khan MI. Usman HR, Azam SI. Khalil M. Amhad K. Pattern of health care utilization and determinants of care-secking from GPs in two districts of Pakistan Southeast Asian J Trop Med Public health 2006 (In press).
20. Luby SP. Niaz Q. Siddiqui S. Mujeeb SA, Fisher-Hoch S. Patients’ perceptions of blood transfusion risks in Karachi, Pakistan. Int J Infect Dis 2001; 5: 24-6.


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