Welcome to Journal Of Pakistan Medical Association

 Supplement Vol:63, No:12 December, 2013

Editorial >>

Insulin Glargine - another gift for people with diabetes

Dr. Fatema Jawad,

Insulin has been called the "Gift of Life" for people with Diabetes especially Type 1 Diabetes. Its discovery by Frederick Banting and Charles Best in 1921 brought a revolution in the history of medicine. Initially it was a crude pancreatic extract which gave back life and health to man....


Professor M. Zaman Shaikh,

The potential advantages of the long-acting insulin analogues are reviewed in this special supplement of Journal of Pakistan Medical Association (JPMA).
Minimizing the risk of hypoglycemia while preventing the devastating complications of T2DM is a significant challenge facing primary care....


Dr. Khursheed Khan,

Type II diabetes mellitus is a progressive disorder which can be managed with oral antidiabetic initially but eventually most patients require insulin to maintain glucose control. Optimal insulin therapy should mimic the normal physiologic secretion of insulin and minimize the risk of hypoglycemi....


Dr. Saeed A. Mahar,

The potential advantages of the long-acting insulin analogues are reviewed in this special supplement of Journal of Pakistan Medical Association (JPMA).
As shown in many clinical studies of basal insulin vs. regular insulin there are no improvement in HbA1c levels; however, the ability to ....

Message >>

Insulin Glargine: A treatment option in Pakistan

Professor Dr. Rauf Niazi,

Insulin analogues have made a dramatic entrance into the diabetes management armamentarium. Most attention has focused on short-acting insulin analogues. Recently, a new long-acting insulin analogue, glargine, has been introduced for patient use. A single injection of basal insulin with insulin b....

Chinese J Evidence-Based Medicine, 2004, Vol. 4(7) >>

Evaluation of the Efficacy and Safety of Once Daily Injection of Glargine Combined with Glipizide GITS in the Treatment of Type 2 Diabetes Mellitus

BU Shi, XING Xiao-yan, WANG Na, ZHAO Wen-hui, YANG Wen-ying,

Objective: To compare the blood glucose level and associated hypoglycemia risks by using insulin Glargine or human NPH both combined with Glipizide GITS in the treatment of type 2 diabetic patients.
Methods: Fifty-six cases with inadequate glycemia control by sulfonylurea and....

Chin J Endocrinol Metab, August 2006, Vol. 22, No. 4 >>

Insulin Therapy and Blood Glucose Monitoring Evaluation of the Superiority of Glargine as Basal Insulin Replacement by Continuous Glucose Monitoring System

WANG Xian-ling, Lu Ju-ming, PAN Chang-yu, MU Yi-ming, DOU Jing-tao, BA Jian-ming,

Summary: With the continuous glucose monitoring system, daily blood glucose profiles were compared in type 2 diabetic patients treated with glargine or neutral protamine hagedorn (NPH) at bedtime for 12 weeks. The blood glucose levels in these patients were previously not well controlled w....

Chin J Diabetes, September 2009, Vol. 17 No. 9 >>

A Study on the Control of Fasting and Postprandial Hyperglycemia by Glargine Insulin Combined with Oral Hypoglycemic Agent

ZHU Li-qun, GU Qing-kui, Zhang Yuan,

Objective: To investigate the effect and safety on the control of fasting and postprandial hyperglycemia by glargine insulin combined with oral hypoglycemic agents (OHA).
Methods: 136 T2DM cases with not well controlled hyperglycemia were divided randomly into groups A and B.....

Chin J Diabetes, May 2010, Vol. 18, No. 5 >>

Studies of pharmacokinetic, pharmacodynamic properties and bioequivalence of recombinant insulin glargine injection in healthy man

CHENG Shi-wu, LU Jun-ming, PANG Chang-yum,

Objective: To study the pharmacokinetic and pharmacodynamic properties of the subcutaneously injected long-acting insulin analog-recombinant insulin glargine injections in comparison with those of reference preparation-NPH insulin injection ( Novolin« N) in healthy volunteers, and to e....



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