ONLINE SUBMISSION
  February, 2012

My Patient has an elevated hs-CRP. What does this mean? What should I do now?

  Maria Khan  ( International Cerebrovascular Translational Clinical Research Training Program, Stroke Service, Aga Khan University Hospital, Karachi, Pakistan. )
Emmon Raza  ( Medical College, Aga Khan University Hospital, Karachi, Pakistan. )
Ayeesha Kamran Kamal  ( Stroke Service and Vascular Fellowship Program, Aga Khan University Hospital, Karachi, Pakistan. )
 


Why is this trial important?
Hyperlipidaemia is an established risk factor for cardiovascular and cerebrovascular disease. A standard investigation to assess a person's hyperlipidaemia is the lipid profile. This measures total cholesterol, high density lipoproteins (HDL), low density lipoproteins (LDL) and triglycerides. LDL has been implicated most as the culprit behind these vascular events. However, new research has shown that a raised high sensitivity C - reactive protein (hs-CRP), a biomarker for inflammation, is a predictor for systemic vascular endothelial inflammation and future vascular event independent of a person's LDL level.
Statins, the wonder drug for high LDL and cholesterol, have been in use for vascular protection for long. They have an established benefit for cardioprotection and stroke risk reduction in people with high cholesterol. However, if statins offer any benefit in people with low to normal Cholesterol and raised hs-CRP was not known.
The JUPITER trial was undertaken with the objective of assessing the benefits of statins in reducing the risk of future vascular events in asymptomatic patients with cholesterol already in the desirable range but elevated hs-CRP.
Who were the participants?
A total of 17,802 individuals from 26 countries were enrolled for the trial. There was representation of Caucasians, Blacks and Hispanics from North and South America, Africa and Europe.
Men aged > 50 years and women aged > 60 years with no vascular co-morbidities and LDL level <130 mg/dL and hs-CRP level > 2.0 mg/dL were eligible.
The study population had a mean age of 66 years with slight male preponderance. Study participants matched in terms of their co-morbidity status.
What was the intervention?
JUPITER was a double-blind, placebo-controlled trial. The study subjects were randomly allocated to two groups. The intervention group was administered 20 mg Rosuvastatin daily. The control group received a placebo pill. The two groups were followed for a median duration of 1.9 years and their lipid levels and hs-CRP were assessed both at baseline and yearly thereafter for as long as they were part of the study. The primary end-point of interest was fatal and non-fatal stroke.
What was the outcome?
At the end of the study period, the incidence rate for stroke in the Rosuvastatin group was 0.18 compared with 0.34 in the placebo group (p=0.002) translating to a 48% risk reduction. Although Rosuvastatin reduced the risk of ischemic stroke compared to a placebo (p=0.004), it was similar to placebo in preventing haemorrhagic stroke (0.44) and transient ischaemic attack (p=0.79). No excess risk of haemorrhagic strokes was observed with statin therapy.
The benefits of therapy extended beyond the high risk group. People who were categorized as low risk based on body mass index <25 kg/m2, without the metabolic syndrome, with a Framingham risk score <10, with low levels of LDL-C (<100 mg/dL), with normal levels of HDL-C), and with normal triglyceride levels (<150 mg/dL) also had similar benefits from therapy.
Twelve months of daily 20 mg Rosuvastatin was able to bring down the LDL and Cholesterol levels by 50% and the hs-CRP levels by 37%. The greatest stroke risk reduction with Rosuvastatin was seen in participants who achieved LDL <70 mg/dL and hs-CRP < 2 mg/L.
The adverse effect profile was similar in both groups except a slightly high incidence of Diabetes in the Rosuvastatin group (p=0.01).
What were the conclusions?
The investigators concluded that use of prophylactic cholesterol-lowering therapy is justified in people with normal-range LDL and cholesterol but raised hs-CRP. Daily use of 20mg Rosuvastatin was associated with a 39% relative reduction in ischaemic stroke risk for each 1mmol/L reduction in LDL level.
Other trials, namely, WOSCOPS, MEGA, AFCAPS-TexCAPS; have proven the advantage of statin therapy on stroke risk reduction in people with high LDL levels and JUPITER proves it in people with desirable LDL and raised hs-CRP levels.
What implications does this study have for the Pakistani medical practitioners?
Daily Rosuvastatin promises reduction in the risk of stroke by 48% in people with normal-range cholesterol who are nonetheless at risk for vascular events due to elevated hs-CRP levels. This is a new vascular intervention point to consider in asymptomatic patients with LDL<130 but raised High Sensitivity C reactive protein levels above 2.


Acknowledgement

Dr Maria Khan is a neurovascular research fellow whose training is currently funded by Award Number D43TW008660 from the Fogarty International Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Fogarty International Center or the National Institutes of Health.


Recommended Reading

1.Everett BM, Glynn RJ, MacFadyen JG, Ridker PM. Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). Circulation 2010; 121: 143-50.
2.Ridker PM, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Khurmi NS, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Trial Study Group. Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein. Am J Cardiol 2007; 100: 1659-64.
3.Ridker PM; JUPITER Study Group. Rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: rationale and design of the JUPITER trial. Circulation 2003; 108: 2292-7.


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Dear Friends and Colleagues,
May you have a very Happy EID with your friends and Family.
May all of us be Blessed with peace and tranquility.
Let us all jointly say a prayer for all troubled persons all over the world
Warm regards,
Dr. Fatema Jawad
Editor-in-chief,
Journal of Pakistan Medical Association, Karachi
President, PAME
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WHO/GOARN Request for technical assistance for Cholera Control in Northern Iraq

Request for assistance

WHO is requesting assistance from GOARN partners to identify the following cholera and diarrhoeal diseases expertise to support the Ministry of Health of Iraq in cholera risk assessment and immediate preparedness activities to improve the health outcomes of the Syrian refugees current living in camps in the Kurdistan region of Iraq.

  • two (2) epidemiologists
  • two (2) clinical management experts
  • one (1) environmental health expert (WATSAN)
  • one (1)laboratory expert

Duration

6 day mission starting 13 June 2014 (this excludes travel time).

Location

Northern Iraq (Kurdistan region).

Language requirements

All candidates must be fluent in English- written, spoken and comprehension. Fluency in Arabic is an asset. Knowledge, abilities and skills All candidates are expected to demonstrate the following

  • Ability to conceptualize and promote innovative strategies and policies.
  • Ability to communicate and write in a clear concise manner, and to develop effective guidelines.
  • Excellent negotiation and interpersonal skills complemented by ability to motivate and lead others and to promote consensus. Tact, discretion and diplomacy
  • Demonstrated ability for project appraisal, project management, monitoring and evaluation and project impact assessment.
  • Ability to work with host governments and their agents, INGOs and national NGOs an advantage.
  • Proven experience of managing a large workload and multiple priorities.
  • Ability to work in difficult conditions.

Support to the mission

WHO/GOARN will cover the travel and per diem (to cover daily expense in the field) expenses for the duration of their mission. GOARN missions do NOT offer salary, consultancy fees or any other form of remuneration.

WHO will provide appropriate logistics support for the field mission. Pre-deployment orientation/training may be required at WHO.

Partners offers of assistance

Partners are requested to reply with offers of assistance, together with CVs and details of the availability of staff for this mission by email to goarn@who.int latest by 30 May 2014. Details of all offers from partners and eventual deployments will be maintained on the GOARN SharePoint.

Operational Contacts

Mamunur Malik WHO EMRO malikm@who.int

William Perea WHO HQ pereaw@who.int

Patrick Drury GOARN druryp@who.int



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