ONLINE SUBMISSION
  February, 2007

Radical vulvectomy by two different surgical incisions

  Nadra Sultana, Sobia Naz  ( Department of Obstetrics and Gynaecology, Foundation University Medical College, Fauji Foundation Hospital, Rawalpindi. )
 

Abstract

Objective: To determine the outcome of radical vulvectomy by two different surgical incisions (butterfly vs triple incision) for the treatment of vulval carcinoma.

Methods:
A comparative study was conducted from January 1992 to July 2003 at Military Hospital Rawalpindi and Fauji Foundation Hospital Rawalpindi. A total of 35 patients were included in this study. One patient received supportive therapy at stage IVB. Out of 34 patients, 23 (67.64%) underwent radical vulvectomy by butterfly incision and 11 (32.35%) radical vulvectomy by triple incision technique. Data regarding history, clinical examination, surgical procedures, per-operative complications, post-operative complications, hospital stay, recurrence and mortality was collected and analyzed.

Results:
The percentages of partial wound dehiscence (86.36% vs 18.18% p=0.00), wound induration (100% Vs 72.7%, p=0.008), infection (22.72% Vs: 9.09%, p=0.637) and lymphoedema (9.0% vs Zero, p=0.542) were higher in butterfly incision group as compared to triple incision group respectively. The per-operative blood loss (750 ± 36.9ml vs 381 ± 14.7ml, p-value: < 0.01), operative time (136.91 ± 14.73 min Vs 81.82 ± 14.71 min, p= 0.00) and hospital stay (19.05 ± 3.27 days Vs 9.09 ± 0.7 days, p=0.00) were significantly higher in butterfly incision as compared to triple incision respectively. The recurrence rate in butterfly incision was comparable to triple incision group (14.28% vs 18.18%, p=0.572). In the butterfly group one patient died per-operatively and another patient died within one year after surgery.

Conclusion: Radical vulvectomy by triple incision has comparable recurrence rate but significantly less mortality and morbidity rates when compared to butterfly incision (JPMA 57:74;2007).


Introduction
Cancer of vulva accounts for approximately 4% of all gynaecological malignancies.1 About 80-90% of primary vulval malignancies are squamous cell carcinoma.2 In United States, invasive vulval cancer occurs with an average annual age adjusted, incidence of 12 per 100,000 women/year.3 The median age for invasive vulval carcinoma is about 65-70 years.4 There is a strong association between human papilloma virus (HPV) infection and subsequent development of vulval carcinoma.5 But in older patients generally there is history of vulval inflammation or lichen sclerosus.6,7

The lymphatics of the vulva and distal third of the vagina drain into the superficial inguinal nodes and travel through the deep femoral lymphatics as well as the node of cloquet to the pelvic nodal group. The stages defined by international Federation of Gynaecology (FIGO) 1995, and American Joint Comission of Cancer (AJCC) 1992, provide far better discrimination of survival than previously described classifications, because of their histo-pathological basis.8

Traditionally carcinoma of vulva has been treated by radical vulvectomy with groin and pelvic node dissection.9-11 Over recent years, the management of this cancer has undergone considerable evolution with emphasis, now being placed on the tailoring of surgery to each case, rather than a bland surgical treatment policy.11-13 Survival positively correlates with aggressive surgery at the time of diagnosis, specifically radial vulvectomy and bilateral inguino-femoral lymph node dissection. Significant morbidity, however, such as wound infection, necrosis, seroma, lymphocyst, venous thrombosis, lymphangitis and chronic lymphoedema has been reported in over 50% patients so treated.14,15 There is more onus on clinicians to provide less radical but equally curative treatment, while also reducing morbidity.16

The previous en-bloc radical vulvectomy with bilateral inguino-femoral lymph node dissection has been replaced by three separate vulvar and groin incisions. This less aggressive approach has been validated by comparable survival trends, with a concomitant decrease in morbidity.17,18

Radical vulvectomy can be performed by butterfly incision as well as triple incision. The butterfly incision technique involves en-bloc removal of lymph nodes along with vulvectomy, through a single incision. This technique causes increased per-operative blood loss, operative time and severe post-operative morbidity. It includes physical as well as psychosexual morbidity. The morbidity of this operation can be reduced by the triple incision technique. It is performed by three separate incisions two for bilateral groin lymph nodes and a separate incision for vulvectomy.

The objective of this study was to determine the outcome of radical vulvectomy by two different surgical incisions, so that a technique could be found exhibiting comparable curative rates with traditionally adopted techniques but having less mortality and morbidity.

Patients and Methods
It was a comparative study, conducted at Military Hospital, Rawalpindi and Fauji Foundation Hospital Rawalpindi, from January 1992 to July 2003. Patients, with the suspicion of carcinoma of vulva, were admitted in the hospital. Patient's history was taken and clinical examination performed. Laboratory investigations included complete blood count, random blood glucose and serum creatinine. Excisional tissue biopsy was taken under local anaesthesia for histopathological diagnosis of vulval disease. Only patients with histopathological diagnosis of vulval carcinoma, were included in the study, whereas cases with Vulval intra-epithelial neoplasia and Extra-mammary Paget's disease were excluded.

A total of 35 patients with confirmed hiso-pathological diagnosis of vulval carcinoma were offered surgical treatment, of these, one patient declined and was discharged on supportive and symptomatic treatment. The remaining 34 patients were counseled about kind of treatment, type of incision and written consent was taken. Convenient sampling technique was used for the study and approval was obtained from the Institutional Ethics Committee. Pre-operative assessment and investigations were performed for surgery and anaesthesia.
Out of 34 patients, 23 (67.64%) underwent radical vulvectomy by butterfly incision and 11 (32.35%) patients by triple incision. General anaesthesia was administered in all patients. During operation, patients were placed in "Ski position" with adjustable stirrups, so that legs could be elevated to high lithotomy, during the perineal phase of operation. Radical vulvectomy with bilateral inguino-femoral lymphadenectomy was performed, with two teams and dissection of each groin was performed simultaneously.

In butterfly incision, a single incision was made, starting from 2 cm medial and about 2 cm caudal to anterior superior iliac spine, curving downwards, above the superior border of inguinal ligament, to the inguinal ring including the mons pubis. Through this incision bilateral inguino-femoral lymphadenectomy was performed. The same incisions were continued downwards along the labiocrural folds on each side and across the perineum, where they meet. A medial mucosal incision was made along the introitus, extending through the anterior vestibule and around the urethral meatus. Attempts were made to attain, at least 2 cm margin of normal specimen. The wound was copiously irrigated. Haemostasis was secured and groin wounds were closed in layers. Drains were inserted through separate incisions bilaterally. Vulval wound was closed with delayed absorbable sutures.

In triple incision, crescent shaped incisions were made bilaterally for groin dissection on same anatomical points. Having completed the groin nodes dissection, wounds were closed, followed by separate incision for vulvectomy, in similar fashion, as in butterfly incision.
Per-operative complications, blood loss and operative time were noted in both types of incision techniques. Post-operative care included daily sitz baths and perineal hygiene. Foley catheter was retained for 3-5 days. Drains were removed, when drainage was approximately 25 ml/day. During course of admission, immediate post-operative complications were noted and patient was discharged according to the condition. Patients were advised fortnightly follow up in outpatient department for detection of delayed post-operative complications. After healing of the wound, patients were referred for radiotherapy. Follow up was at threes monthly for two years, and six monthly for next three years.

Data were collected on pre-designed proforma where all relevant variables pertaining to the study were recorded. Statistical analysis was done by using SPSS version 10. The t-test was applied for comparison of quantitative data and chi-square test for qualitative data.

Results
Out of 35 patients, 22 (63%) were between 60-69 years of age and 9 (25.7%) between 51-59 years, 3 (8.5%) >70 years and 1 (2.8%) < 50 years of age. Most common presenting complaints were pruritis vulvae (75%) and vulval ulceration (42%). Vulval mass was the presentation in 18% patients. A total of 29 (82.8%) patients presented at stage IVA, 04 (11.4%) at stage-III, 1 (2.8%) at stage-I, 1 (2.8%) at stage-IVB. Histopathology reports revealed squamous cell carcinoma in 33 (94%) patients, melanoma in 1 (3%) and verrucous carcinoma in 1 (3%) patient.

One patient died per-operatively in butterfly incision group due to massive haemorrhage. The per-operative blood loss (750.00 ± 36.93ml vs 381 ± 14.73ml, p=0.00), operative time (136.91 ± 14.73 min vs 81.82 ± 14.71 min, p=0.00) and hospital stay (19.05 ± 3.27 days vs 9.09 ± 0.7 days, p=0.00) were significantly higher in butterfly incision as compared to triple incision respectively (Table 1).

[(0)]
[(1)]

The percentages of partial wound dehiscence (86.36% vs 18.18% p=0.00), and wound induration (100% vs 72.7%, p=0.008), were significantly higher in butterfly group as compared to triple incision group. (p=0.05).

Lymphoedema (9.0% vs Zero, p=0.542) and infection (22.72% vs 9.09%, p=0.637) were more in butterfly incision as compared to triple incision group respectively but statistically insignificant (Table 2).
Patients could be followed up for one year as after that most of them were lost to follow up. One patient died within one year of operation in butterfly group. The recurrence rate in butterfly incision was comparable to triple incision group (14.28% Vs 18.18%, p=0.572) (Table 3).

Discussion
In this study, two different operative techniques were used for radical vulvectomy and results were analyzed. It was found that recurrence rate was comparable in both techniques but mortality and morbidity were significantly less in triple incision technique as compared to the butterfly incision technique.
Helm CW19 compared single and triple incision for radical vulvectomy in 64 patients and observed that patients with triple incision had a significantly shorter operative time, less blood loss, and a minimal hospital stay. No difference was observed in the survival or recurrence rate between the two groups, and none of the women in the triple incision developed skin bridges metastasis. Higher morbidity rate was encountered in single incision group as compared to triple incision.

Gleeson20 found similar results in his study. He concluded that separate vulval and groin incision have significantly reduced morbidity for vulval cancer surgery. Although rare, the potential for failing to excise the tumour emboli in the lymphatics of the skin bridges must be recognized when triple incision technique is used in surgical treatment of vulval carcinoma.

In management of vulval cancer, as far as the surgical approach is concerned, the nature and the extent of the surgery undertaken should be influenced by the stage of the disease, the location of the tumour and the patient's condition. The effect of radical vulvectomy is limited by the closest resection margin, rather than the achievement of total organ ablation. A more conservative surgery is best for most women with vulval cancer. Main objective is to cure the disease while still allowing patients to lead happy and healthy lives.21

Ansink11 concluded that radical local excision, ipsi-lateral lymph-node dissection in lateral tumours and triple incision technique are safe treatment options for early vulval cancers. However the superficial groin node dissection results in an excess of groin recurrence, compared to the full femoro-inguinal groin node dissection.

Hence, management of vulval cancer has been modified according to site, size, and stage of lesion. Aggressive surgical treatments are discouraged and treatment is tailored for each patient individually. Micro-invasive cancer does not require node dissection, limiting the inguinal node dissection to one side in the, small localized tumours using a triple incision technique instead of an en-bloc approach.8

Lymph node dissection is the single most important factor in reducing early recurrence and mortality. Extensive lymphadenectomy, however is also a major etiologic factor in immediate and long term morbidity. If the extent of inguino-femoral dissection could be reduced without comparison of diagnostic and therapeutic accuracy, morbidity would be substantially reduced. Sentinel lymph node detection (SLND), is an investigational method that could accomplish these objectives.22-25 By SLND, morbidity rate can be reduced by avoiding un-necessary extensive lymphadenectomy.

Conclusion
Radical vulvectomy by triple incisions has comparable recurrence rate when compared with butterfly incision but radical vulvectomy by triple incision has significantly less mortality and morbidity rates as compared to butterfly incision.

References
1. Parker SL, Tong T, Bolton S: Cancer Statistics, CA Cancer J Clin 1997; 47: 5.

2. Macnab JC, Walkinshaw SA, Cordiner JW. Human Papilloma virus in clinically and histologically normal tissue of patients with genital cancers. N Engl J Med 1986; 315:1052-58.

3. Stugreon SR, Brinton LA, Devesa SS: In situ and invasive vulvar cancer incidence trends (1973-1987) Am J Obstet Gynecol 1992; 166:1482-5.

4. Eifel PJ, Berek JS, Thigpan JT. Cancer of cervix, vagina and vulva, In: Devita VT, Hellman S, Rosenberg SA, editor cancer: Principle and practice of Oncology, 5thed. Philadelphia: Lipincott Raven 1997, pp 1433-78.

5. Brinton LA, Nasa PC, Mallin K: Case control study of cancer of the vulva. Obstet Gynecol 1990; 75:859-66.

6. Toki T, Kurman RJ, Park JS: Probable non-papilloma virus eitiology or squamous cell carcinoma of vulva in older women. A clino-pathological study using in-situ hybridazation and PCR. Int J Gynecol Pathol 1991; 10:107-25.

7. Carli P, Demagnis A, Mannone F, Botli E, Taddei G, Cattaneo. A Vulvar carcinoma associated with lichen sclerosus. J Reprod Med, 2003; 48:313-18.

8. Nauman RW. Surgical treatment of vulvar Cancer [online] November 11, 2004 [cited14February2005] available from: URL: http/www.e-medicine.com.

9. Taussig FJ. Cancer of the vulva: an analysis of 155 cases (1911-1940) Am J Obstet Gynecol 1940; 40:764-79.

10. Way S. Results of a planned treatment attack on carcinoma of the vulva. Br Med J 1954; 4891:80-2.

11. Ansink A, Vander VJ. Surgical intervention for early squamous cell carcinoma of the vulva (Chochrane Review) In: The Cochrane Library, Issue 4, 2001. Oxford Update Software.

12. Thomas GM, Dembo AJ, Bryson SC, Osborn R, De Petrillo AO. Changing concepts in the management of vulvar cancer. Gynecol Oncol 1991; 42: 9-21.

13. Hacker NF, Vander VJ. Conservative management of early vulvar cancer. Cancer 1993; 71:1673-4.

14. Cavanagh D, Fiarica JV, Hoffman MS, Roberts WS, Bryson SC, Lopolla J Petad. Invasive carcinoma of the vulva: Changing trends in surgical management. Am J Obstet Gynecol 1990; 163:1007-15.

15. Burke TW, Stringer CA, Gershenson DM, Edwards CI, Morris M, Wharton JT, et al. Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva. Gynecol Oncol 1990; 38:328-32.

16. Barton DP. The prevention and mangement of treatment related morbidity in vulvar cancer. Best Pract.Res Clint Obstet Gynecol 2003; 17: 683-701.

17. Hopkin MP, Reid GC, Morley GW: Radical Vulvectomy. The decision for the incision. Cancer 1993; 71:1675-7.

18. Morgan MA, Mikuta JJ. Surgical management of vulvar cancer. Semin Surg Oncol 1999; 17 : 168-72.

19. Helm CW, Hatch K, Austin JM. A matched comparison of single and triple incision technique for the surgical management of carcinoma of the vulva. Gynecol Oncol 1992; 46:150-5.

20. Gleeson NK, Hoffman MS: Isolated skin bridge metastasis following modified radical vulvectomy and bilateral inguino-femoral lymphadenectomy. Int J Gynecol Cancer 1994; 4:356-8.

21. Podratz KC, Cornello J, Weaver A, Gaffery TA. Fewer complication with modified Radical surgery of the vulva, Gynecol Oncol 1999; 13:1-2.

22. Hoffman MS. Malignancies of the vulva. In: Rock J A, Jones HW, ninth ed. Te-lindes's operative Gynaecology. Philadelphia: Lippincott William and Wilkins, 2003: pp 1293-1350.

23. De Hulla JA, Hollema H, Piers DA. Sentinel lymph node procedure is highly accurate in squamous cell carcinoma of the vulva. J Clin Oncol 2000; 18:2811-16.

24. Terada KY, Shimizu DM, Wong JH. Sentinel node dissection and ultrastaging in squamous cell cancer of the vulva, Gynecol Oncol 2000; 76:40-4.

25. Makar APH, Scheistroen M, Van-der Weyngaert D, Trope CG. Surgical management of stageI and II, vulvar cancer: the role of sentinel node biopsy. Review of literature. Int J Gynecol Cancer 2001; 11:255-62.

News & Events

The Sixth Regional Conference on Medical Journals in the Eastern Mediterranean Region(EMMJ6) will take place from February 18-20,2015 in Shiraz,Islamic Republic of Iran.
Important dates:
Abstract Submission Deadline: January 15,2015
Abstract Acceptance Notification: January 22,2015
Registration (Conference and Workshops) Deadline: January 30,2015


http://emmj6.sums.ac.ir



SIUT SYMPOSIUM DECEMBER 2015

Sindh Institute of Urology and Transplantation (SIUT), Karachi will celebrate 40 years of its services by holding an International Symposium on Recent Advances in Urology, Nephrology, GI Hepatology, Paediatrics, Transplantation & Bioethics from 8th to 12th December, 2015.Social and economic aspects of health care especially in a developing country will also be included.
Important Dates: Last date for Abstract submission:31st July 2015
Last Date for early registration: 30. September, 2015



News



Index



Supplement