Issue Vol:61, No:2 February, 2010

Editorial

Whistleblowing: do we have courage?
Muhammad Hanif Shiwani, Amin A Gadit,

A doctor's primary duty is to provide a safe medical practice and make sure all patients receive safe care. If health care professionals suspect that their patients are at risk, it is their professional duty to blow out the whistle. It sounds simple but how many people can blow a whistle.

Original Articles

Has the anterolateral thigh flap replaced the latissimus dorsi flap as the workhorse for lower limb reconstructions?
Muhammad Sarmad Tamimy, Mamoon Rashid, Ehtesham-ul-Haq, Sameena Aman, Ayesha Aslam, Rao Saod Ahmed,

Objective: To compare the applicability and reliability of free Anterolateral thigh flap (ALTF) with Latissimus Dorsi free flap (LD) in different reconstructive scenarios of lower limb. To compare flap elevation time, vessel diameters, pedicle lengths, total operative time, peri-operative blood requirement, number of secondary procedures ....

Father’s support and literacy — factors associated with child mortality in Gambat, Sindh-Pakistan
Ajmal Agha, Fozia Ajmal, Azam Iqbal, Franklin White,

Objectives: To determine Under Five Mortality Rate (U5MR) in Gambat and to identify causes of and factors associated with it.
Methods: The study was conducted in taluka Gambat of Sindh, Pakistan from December 2002 to August 2003. The sample of at ....

Changing trend of viral hepatitis — “A twenty one year report from Pakistan Medical Research Council Research Centre, Jinnah Postgraduate Medical Centre, Karachi”
Waquaruddin Ahmed, Huma Qureshi, Ambreen Arif, Syed Ejaz Alam,

Objective: To determine the frequency and pattern of Hepatitis B and C over the past twenty one years, in a liver research unit of Karachi.
Methods: Retrospective analysis of the records of PMRC, Research Centre, Jinnah Postgraduate Medical Centre....

Anatomical variations and congenital anomalies of Extra Hepatic Biliary System encountered during Laparoscopic Cholecystectomy
Khamiso Altaf Hussain Talpur, Abdul Aziz Laghari, Sikandar Azam Yousfani, Arshad Mahmood Malik, Aamir Iqbal Memon, Sangrasi Ahmed Khan,

Objective: To assess the frequency of anatomical variations of extrahepatic biliary system in patients undergoing laparoscopic cholecystectomy.
Methods: This is an observational study performed in the Department of Surgery, Liaquat University of M....

Fighting lung cancer in the developed world - a model of care in a UK hospital
Inam Mohammad Baig, Penny Downer, Robert Milroy,

Objectives: To highlight the initial management approach for Lung Cancer in a UK Hospital with the aim of translating the principles of such methodology to a developing country, such as Pakistan.
Methods: A descriptive observational study was carr....

Correlation of Eosinophil Derived Neurotoxin with airway resistance in asthmatics
Ahmed Badar, Muhammad Mazhar Hussain, Waseem Saeed, Muhammad Aslam,

Objective: To determine the correlation of EDN with lung function tests (FVC, FEV1, FEV1/FVC and FEF25-75%) in asthmatics and to compare these with matched controls.
Methods: This study was carried out at Army Medical College & Military Hospit....

Factors associated with recurrent nasal polyps: A tertiary care experience
Shabbir Akhtar, Mubasher Ikram, Iqbal Azam, Tariq Dahri,

Objective: To assess the factors associated with recurrence of nasal polyps in operated patients by endoscopic surgery.
Methods: A retrospective study was conducted on 192 patients operated for nasal polyps in a hospital set-up between 2001 and 20....

Extrapulmonary Tuberculosis: A retrospective review of 194 cases at a tertiary care hospital in Karachi, Pakistan
Subash Chandir, Hamidah Hussain, Naseem Salahuddin, Mohammad Amir, Farheen Ali, Ismat Lotia, Amir Javed Khan,

Objective: To describe the types and treatment outcomes of the extra-pulmonary tuberculosis (EPTB) cases in a tertiary care hospital in a high burden tuberculosis country.
Method: A retrospective case series study was conducted at Liaquat National....

Long-term outcome of Trans Urethral Prostatectomy in benign prostatic hyperplasia patients with and without diabetes mellitus
Mohammad Soleimani, Seyed Yousef Hoseini, Majid Aliasgari, Farid Dadkhah, Alireza Lashay, Erfan Amini,

Objective: To compare the different aspects of the postoperative outcomes in diabetics and nondiabetics of transurethral prostatectomy in patients with benign prostatic hyperplasia.
Methods: From December 2000 to December 2003, a total of 138 men ....

Sublingual versus vaginal misoprostol in the management of missed miscarriage
Nusrat Shah, Syed Iqbal Azam, Nusrat Hasan Khan,

Objective: To compare the efficacy of sublingual and vaginal misoprostol in the medical management of missed miscarriage.
Methods: Fifty women diagnosed as having missed miscarriage of gestational age less than 20 weeks were assigned randomly to r....

Frequency of hyponatraemia and its influence on liver cirrhosis-related complications
Samiullah Shaikh, Gomo mal, Shaikh Khalid, Ghulam Hussain Baloch, Yousfani Akbar,

Objective: To evaluate the frequency, clinical associations and prognostic impact of hyponatraemia on cirrhosis related complications in patients with cirrhosis of liver.
Methods: In this case control study 217 cirrhotic patients consecutively adm....

Review Articles

Antibiotics in Acute Necrotizing Pancreatitis — Perspective of a Developing Country
Afrasyab Khan, Sadaf Khan,

Prophylactic antibiotics in acute necrotizing pancreatitis is controversial. The mortality of acute necrotizing pancreatitis is 8-25% in the western world. In view of the limited resources available for managing the complications of infected pancreatitis in developing countries, the use of prophylactic antibiotics may be reco....

Short Communication

Efficacy and safety of procedural sedation and analgesia by paediatric intensivist in paediatric oncology unit
Anwarul Haque, Zahra Fadoo,

Children with cancer especially acute leukaemia undergo multiple painful procedures like bone marrow biopsy (BM) and lumber puncture (LP) for intrathecal chemotherapy during their first year of treatment. The purpose of this study is to report safety and efficacy of Procedural Sedation and Analgesia (PSA) by paediatric intens....

Case Reports

Adolescent menorrhagia due to platelet function disorder
Nazli Hossain, Tasneem Farzana, Nusrat Hasan Khan, Tahir Sultan Shamsi, Andra H James,

The prevalence of menorrhagia in adolescent populations with bleeding disorders varies between 14% to 48%. The common conditions associated with menorrhagia include von Willebrand disease (VWD), platelet function disorders and coagulation factor deficiencies. The majority of studies, which have been conducted in the West, rep....

Superior Forniceal Advancement Conjunctival Pedicle (SFACP) in the management of corneal perforations and impending perforations due to rheumatoid arthritis related autoimmune corneal melts
Muhammad Amer Awan, Kanna Ramaesh,

Peripheral ulcerative keratitis (PUK) is a disorder consisting of a crescent-shaped destructive inflammation of the perilimbal corneal stroma. PUK may occur in variety of systemic diseases including collagen vascular disease. We describe the outcome of superior forniceal advancement conjunctival pedicle (SFACP) in two patient....

Identification of internal carotid artery dissection in patients with Migraine — Case report and literature review
Muhammad Sharif, Tom Trinick, Khurum Hayat Khan,

Although patho-physiology of spontaneous internal carotid artery dissection (sICAD) is largely unknown, an association with migraine has been suggested but not proven.
Migraine is a condition which is worth considering while one is hunting a possible cause for internal carotid art....

Granulocytic Sarcoma of the Small Intestine: An Unusual Presentation of Acute Myelogenous Leukaemia
Tariq Ghafoor, Alia Zaidi, Ibrahim Al Nassir,

Granulocytic sarcoma is an extramedullary tumour of primitive granulocytic cells. It can develop at any anatomic site and is often a forerunner to the development of acute myelogenous leukaemia. Granulocytic sarcoma of the small intestine presents with abdominal pain and obstruction. We report a case of a 17-years-old boy who....

Factor VII deficiency and pregnancy: A case report and review of literature
Syed Mohammad Asad Zaidi, Rahat Najam Qureshi, Salman Naseem Adil,

Factor VII deficiency is one of the 'rare inherited disorders of coagulation.' Few cases of Factor VII deficiency have been reported during pregnancy, a state which could potentially cause fatal haemorrhage. Here we report a case of a pregnant lady with a history of heavy menorrhagia and multiple first pregnancy failures. Del....

Acute colonic pseudo-obstruction (ACPO) after normal vaginal delivery
Abu Bakar Hafeez Bhatti, Fahad Khan, Adeel Ahmed,

Acute colonic pseudo-obstruction (ACPO) can occur as a potential complication following various surgical procedures. Whereas several cases of ACPO are documented in the medical literature following Caesarean section (C-section), only rarely has it been described in association with a normal vaginal delivery. We report a 32-ye....

Opinion and Debate

Improving Schizophrenia diagnosis through Biomarkers: An upcoming prospect
Syed Mohammad Asad Zaidi, Abdul Latif Bikak, Rameez-ul-Hassan,

Despite extensive research and deliberation, the diagnoses of schizophrenia and other psychiatric disorders remain enigmatically difficult and the established diagnostic criteria, even after several critical reviews, are continually ill-defined. Indeed, the widely used ICD-10 guidelines are in fact derived from the observatio....

Student's Corner

Gastroesophageal reflux disease (GERD) in students of a government medical college at Karachi
Haris Riaz, Syed Wajahat Kamal, Sina Aziz,

Objective: To assess the frequency of symptoms suggestive of Gastroesophageal reflux disease (GERD) in students of a government medical college at Karachi.
Methods: This is a cross sectional study conducted at Dow Medical College (from September t....

Knowledge, attitudes and practices of medical students regarding needle stick injuries
Taimur Saleem, Umair Khalid, Sidra Ishaque, Afia Zafar,

Objective: To ascertain knowledge, attitude and practices of medical students regarding needle stick injuries.
Methods: A cross sectional survey was conducted among the consenting medical students of 3rd, 4th and 5th years at a teaching hospital o....

Erythrocyte sedimentation rate: Diagnostic value and pitfalls of usage in clinical practice

Madam, the erythrocyte sedimentation rate (ESR), first described by Edmund Biernacki, was considered an exciting addition to the diagnostic armamentarium of the physician and an important aid in the assessment of occult, obscure and elusive presentation of diseases. It gained further popularity when Alf Westergren modified th....

HIV in Pakistan: An emerging menace

Madam, HIV is a growing health concern in this part of the world as we live in a low prevalence high risk country for HIV spread, sharing our borders with the HIV havocked India. IV drug abuse, alarming rise in non-marital sex and lack of knowledge about HIV/AIDS transmission compounded with a lethargic government response an....

Letter to the Editor

Chilaiditi’s syndrome

Madam, Chilaiditi's Syndrome is an infrequent condition with radiological evidence of symptomatic colonic interposition between the liver and diaphragm.1 The diagnosis of this syndrome by erect abdominal and chest plain films is important, and it allows the differentiation from pneumoperitoneum, rupture....

Treating vitamin D deficiency (VDD) can also play a role in fight against chronic diseases

Madam, although the best characterized sequalae of low levels of vitamin D are associated with the musculoskeletal system, recent research identifies the association of many chronic diseases especially high blood pressure, stroke, diabetes and cancer with vitamin D deficiency (VDD).1

“Frequency of hypothyroidism in Patients with b-thalassemia”

Madam, being a part of Thalassemia research ourselves, we read with great interest an original article entitled "Frequency of hypothyroidism in Patients with b-thalassemia" in the recent edition of your respected journal.1 We congratulate the authors in this regard. However, there are certain ....

“Frequency of hypothyroidism in Patients with b-thalassemia”

Madam, reference to my article titled "Frequency of Hypothyroidism in patients of b-Thalassemia" published in the January 2010 issue of JPMA. Thankyou for the feedback.
As regards the comments:
Tests for serum ferritin levels....

Case Series

Successful management of dislodged stents during percutaneous coronary intervention
Muhammad Tariq Farman, Jawaid Akbar Sial, Tahir Saghir, Syed Nadeem Hasan Rizvi, Syed Ishtiaq Rasool, Syed Zahid Jamal,

Stent dislodgement is a very rare but recognized and potentially serious complication of percutaneous coronary intervention (PCI). This case series describe the incidence and etiology of such cases at National Institute of Cardiovascular Diseases, Karachi during the year 2008 and the method of treatment of this complication

News & Events

  • 5th Regional Conference on Medical Journals in the Eastern Mediterranean Region (EMMJ5) December 2-5, 2010 Karachi, Pakistan Information: Pakistan Association of Medical Editors, Address: Room 522, Panorama Centre, Saddar, Karachi, Pakistan Phone: (+92 21) 3568 8791 (+92 21) 3568 9285
    http://www.pame.org.pk/emmj5

  • MESOT (Middle East Society of Organ Transplantation) announces the MESOT Fellowship Programme for 1 -2 years for Physicians and Surgeons from the Middle East Region to acquire skills in various aspects of organ transplantation. This will help in establishing organ transplantation in underserved regions.Application deadline is 30. June each year.For details contact: Bassam Saeed MD.Chairman, MESOT Fellowship Programme, PO Box 8292,Damascus, Syria.E-mail: bassam.said@gmail.comInformation can also be had from:Sind Institute of Urology & Transplantation, Civil Hospital, Karachi.Tel: 2730352. E-mail: info@siut.org

  • The Second Asian and Third National Medical Students` Research Conference will be held at Mangalore, Karnataka (India) from 24th to 28th June, 2009. The conference is being organized by the Indian Forum for Medical Students Research and hosted by Kasturba Medical College Mangalore.More details of the conference can be had from the conference website:http://www.informer.org.in/Conferences
    http://www.informer.org.in/Conferences

Index