Issue Vol:64, No:10 October, 2014


The Frax tool: still under utilized
Sanjay Kalra,

Osteoporosis, and the fractures that result from it, are a global public health issue. The management of osteoporosis has undergone significant changes in the past decades. However, its management is marked by wide disparity, and major differences, across the world. Though the gold standard for d....

Original Articles

Differential expression of Phophatase and Tensin Homologue in normal, hyperplastic and neoplastic endometrium
Summayya Shawana, Shahnaz Imdad Kehar, Fouzia Shaikh,

Objectives: To observe the differential expression of phophatase and tensin homologue in normal proliferative, hyperplastic and malignant endometrial lesions.
Methods: The retrospective study was based on the analysis of endometrial samples, both hysterectomies and curettage,....

The role of Neutrophil Gelatinase-Associated Lipocalin in identifying contrast induced nephropathy development in the emergency department
Sule Akkose Aydin, Suna Pozam, Fatma Ozdemir, Meral Leman Ozkan, Ozlem Koksal,

Objective: To evaluate the diagnostic significance of neutrophil gelatinase-associated lipocalin in detecting the development of contrast-induced nephropathy in patients undergoing contrast imaging in an emergency department setting.
Methods: The case-control study was condu....

Study guide usability survey: Perception of students and teachers of an undergraduate medical college
Shazia Babar, Lubna Baig,

Objectives: To explore the perception about usability of study guide from students and teachers of an undergraduate medical college.
Methods: The cross-sectional study was done at Bahria University Medical and Dental College, Karachi, in May 2012 and comprised 2nd, 3rd and 4t....

Effect of age on uterine and ovarian morphology with Polycystic Ovaries
Ambreen Usmani, Rehana Rehman, Aisha Qamar,

Objective: To measure the outcome of age on ovarian and uterine morphology in primary infertile women with polycystic ovaries.
Methods: The observational cross-sectional study was conducted from January 2009 to March 2010, and the subjects were recruited from Ziauddin Hospita....

A multivariate analysis of factors associated with infant mortality in South-East of Iran
Alireza Ansari-Moghaddam, Simin Sadeghi-Bojd, Mahmoud Imani, Safaneh Movahedinia, Aboozar Pourrashidi,

Objectives: To determine the causes and risk factors of infant mortality.
Methods: The population-based case-control study in 2011 comprised infants under one-year-old who had died at Ali-ebn-Abitaleb Hospital in Zahedan, Iran, during 2011 who were taken as the case group, wh....

Effects of hepatitis C virus gene NS2 on the expressions of Bcl-2 and Bax in HepG2 cells
Wanhu Fan, Fenjing Du, Xiaojing Liu,

Objective: To study the effects of hepatitis C virus gene nonstructural protein 2 on the expressions of Bcl-2 and Bax in liver hepatocellular cells.
Method: The study was conducted at the Department of Infectious Diseases, the First Affiliated Hospital of Medical School, Xi'....

Predictive validity of medical and dental colleges' entrance test in Punjab: The way forward
Junaid Sarfraz Khan, Osama Mukhtar, Saima Tabasum,

Objective: To identify the strengths and weaknesses of the current selection process for admissions to public medical colleges being followed in the province of Punjab and to suggest changes.
Methods: The prospective study comprised candidates sitting the Medical and Dental C....

Frequency of severe vitamin-D deficiency in patients presenting to a tertiary care hospital in Islamabad
Ismaa Ghanzanfar Kiani, Faridullah Shah, Syeda Sabahat Mansur,

Objectives: To determine the frequency of severe vitamin D deficiency in patients presenting in a tertiary care hospital in Islamabad and its possible causes.
Methods: The cross-sectional study involving 351 consecutive patients was conducted at the out-patient department of ....

Magnetic resonance spectroscopy of enhancing cerebral lesions: Analysis of 78 histopathology proven cases
Muhammad Shahbaz Alam, Humera Ahsan, Zafar Sajjad, Madiha Beg, Umer Bhatti, Ather Enam, Muhammad Wasay,

Objectives: To investigate the efficacy of magnetic resonance spectroscopy in differentiating various types of neoplastic and non-neoplastic enhancing cerebral lesions.
Methods: The prospective study was conducted from January 2007 to December 2009 at the Department of Radiol....

Risk factors for intraventricular haemorrhage in preterm infants from a tertiary care hospital of Karachi, Pakistan
Anila Haroon, Humaira Maheen, Muhammad Sohail Salat, Dhanwanti Dileep, Shakeel Ahmed, Ali Syed Muhammad Akhtar, Syed Rehan Ali,

Objective: To determine the incidence of Intraventricular Haemorrhage in pre-term infants, along with adverse neonatal outcomes associated with the disease..
Methods: The retrospective case control study was conducted at Aga Khan University Hospital, Karachi, and comprised pa....

The effects of magnesium sulphate on succinylcholine-induced fasciculation during induction of general anaesthesia
Behzad Ahsan, Ezatollah Rahimi, Afshin Moradi, Naser Rashadmanesh,

Objectives: To investigate the effects of magnesium sulphate on succinylcholine-induced fasciculation in patients during the induction of general anaesthesia.
Methods: The double-blind randomised clinical trial was conducted in 2012 at Tohid and Besat Hospitals in Sanandaj, I....

Four-site skinfolds and body fat percentage references in 6-to-17-year old Turkish children and adolescents
Betul Cicek, Ahmet Ozturk, Demet Unalan, Meral Bayat, Meral Bayat, Selim Kurtoglu,

Objective: As skinfolds from four-sites (triceps, biceps, subscapular, suprailiac) and body fat percentage in 6-17 years is lacking in Turkey. This study was undertaken to produce references for four-site skinfolds and body fat percentage in children and adolescents.

Pedestrian injuries and fatalities by patterns in reported road traffic crashes - Islamabad
Yousaf Zia, Muhammad Sabir, Zia-ul-Islam, Imran Ullah Saeed,

Objective: To find the main cause behind pedestrian injuries and fatalities and to categorise the information on the basis of key indicators.
Methods: The retrospective study was conducted in Islamabad, Pakistan, and was based on the officially-lodged First Information Repor....

Patterns of care and outcomes of adult osteosarcoma in a tertiary care cancer centre in Pakistan
Saba Imtiaz, Ather Kazmi,

Objective: To present our experience of treatment outcomes in adult osteosarcoma patients.
Methods: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data related to 74 adult patients wit....

Clinically significant Coagulase Negative Staphylococci and their antibiotic resistance pattern in a tertiary care hospital
Mohammad Mubashir Ahmad Khan, Aftab Faiz, Ahmad Mohammad Ashshi,

Objectives: To identify various species of coagulase negative staphylococci involved in neonatal septicaemia and determine their antimicrobial resistance pattern.
Methods: The prospective descriptive study was carried out from January 2012 to October 2013, at Umm Al-Qura Univ....

Review Articles

Changes in brain metabolites in experimental cerebral malaria infection with plasmodium berghei ANKA: A literature review
Ali Sibtain Farooq Sheikh, Saman Ali Sheikh, Mona Adel Mohamed,

In this paper, we have collected the findings of available literature focusing on brain metabolites by spectroscopy in the murine model of cerebral malaria disease. The literature search for experimental cerebral malaria (ECM) and spectroscopy using National Institute of Health's PubMed database....

Short Reports

Serum adiponectin levels in diabetes, obesity and gender in Punjabi subjects from Faisalabad, Pakistan
Syeda Sadia Najam, Fazli Rabbi Awan, Shahid Mahmood Baig,

Adiponectin has been associated with common metabolic disorders. The current study was conducted to measure and compare levels of adiponectin with obesity, type 2 diabetes mellitus (T2DM) and gender in Punjabi subjects from Faisalabad, Pakistan. Serum adiponectin was measured by enzyme-linked imm....

Case Reports

Hepatotoxicity associated with the ingestion of Papaver Rhoease
Hayriye Gonullu, Sevdegul Karadas, Ahmet Cumhur Dulger, Senar Ebinc,

Liver injury appears to be associated with the use of herbal products and wild plants. This paper presents what is to our knowledge the first case report in the world of acute liver toxicity caused by Papaver Rhoease. A 17-year-old woman from eastern Turkey ingested Papaver Rhoease which is known....

A chronic eosinophilic pneumonia case with long exposure to isocyanates
Funda Yalcin, Zafer Hasan Ali Sak, Fatima Nurefsan Boyaci, Mehmet Gencer,

Chronic eosinophilic pneumonia (CEP) is a disease with unknown etiology, characterized by peripheral blood eosinophilia and abnormal eosinophil accumulation in the lungs. A 43-year-old male with 30 years history of exposure to isocyanates was admitted with the complaint of sputum, cough, progress....

Transient cortical blindness: A benign but devastating complication after coronary angiography and graft study
Ganiga Srinivasaiah Sridhar, Muhammad Athar Sadiq, Wan Azman Wan Ahmad, Chitra Supuramaniam, Abdul Wahab Undok, Imran Zainal Abidin, Kok Han Chee,

Transient cortical blindness after coronary angiography and bypass graft is a very rare complication. In this report we present the case of a 63-year-old man who developed transient cortical blindness within 30 minutes of coronary angioplasty and graft study, but subsequently recovered within 72 ....

Prolonged mania in a case of bipolar affective disorder
Ather Muneer,

Bipolar disorder, which often has its onset in adolescence or early adulthood, is characterised by marked variations in mood, ranging from major depressive episodes to manic exacerbations. Compared to depressive episodes, manic recurrences are often brief and usually respond to anti-manic medicat....

Anthrax: A Case Report
Ali Bal, Ali BalOnur Gokdemir,

Anthrax is a zoonotic disease caused by a bacterium called Bacillus Anthracis. In humans, it causes a cutaneous, gastro-intestinal and inhalation form of disease. The in-cutaneous form progresses along with skin necrosis and oedema. Since the necroses in the skin are not quite superficial, they c....

Student's Corner

Rotavirus vaccine - a new hope
Haider Ghazanfar, Sajida Naseem, Ali Ghazanfar, Sana Haq,

Diarrhoea due to Rotavirus is the leading cause of mortality among children less than 5 years of age in developing countries. Though Rotavirus vaccine has been approved by FDA since 2006 it has not been incorporated in the EPI schedule of Pakistan. Objective of our study was to explore the clinic....

The decrepit state of trauma care in under-developed healthcare settings
Dania Aijaz Shah, Adil Aijaz Shah,

The escalating number of deaths attributed to injuries in developing countries approximates 90% of trauma-related mortality worldwide.1 Trauma burdens the fragile economic and health environments of developing nations, especially when survival culminates into permanent disa....


Determinants of caesarean section in a tertiary hospital
Sameera Ehtisham, Haleema Akhtar Hashmi,

Objective: To analyse the different indications and frequency of caesarean sections in order to reduce such deliveries in a tertiary hospital.
Methods: The retrospective study was conducted at the Department of Obstetrics and Gynaecology, Liaquat National Hospital, Karachi, f....

Evidence Based Medicine

Early magnetic resonance imaging in transient ischaemic attack and minor stroke
Quratulain Nauman Shaikh, Adeel Ali Memon, Ayeesha Kamran Kamal,

Why is this study Important?
The usage and yield of MRI after minor stroke or TIA can be affected by timing of imaging. As this valuable resource is very expensive and limited in many countries, this study aimed to find the impact of scanning the patient early versus late after TIA ....

Learning Research

How to write an introduction and methods of a systematic review of literature
Muhammad Ashar Malik,

Writing systematic review in English language is challenging for those whose first language is other than English and those who are not primarily trained on writing skill such as medical doctors.1 The guidelines to write and publish a systematic review are usually specific ....

Recent Advances In Endocrinology

Sodium glucose transporter 2 (sglt2) inhibitors: Current status in clinical practice
Deep Dutta, Sanjay Kalra,

Sodium glucose transporter 2 (SGLT2) inhibitors including dapagliflozin, canagliflozin and empagliflozin act by a novel insulin-independent mechanism by blocking glucose reabsorption in the proximal convoluted tubules resulting in markedly increased glycosuria, a mechanism not limited by the degr....

News & Events


Sindh Institute of Urology and Transplantation (SIUT), Karachi will celebrate 40 years of its services by holding an International Symposium on Recent Advances in Urology, Nephrology, GI Hepatology, Paediatrics, Transplantation & Bioethics from 8th to 12th December, 2015.Social and economic aspects of health care especially in a developing country will also be included.
Important Dates: Last date for Abstract submission:31st July 2015
Last Date for early registration: 30. September, 2015




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